Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4670417..4671036 Replicon chromosome
Accession NZ_CP047160
Organism Klebsiella pneumoniae strain KP19-2029

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GSU00_RS22835 Protein ID WP_002892050.1
Coordinates 4670818..4671036 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GSU00_RS22830 Protein ID WP_002892066.1
Coordinates 4670417..4670791 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU00_RS22820 4665569..4666762 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GSU00_RS22825 4666785..4669931 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
GSU00_RS22830 4670417..4670791 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GSU00_RS22835 4670818..4671036 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GSU00_RS22840 4671195..4671761 + 567 WP_002892030.1 maltose O-acetyltransferase -
GSU00_RS28350 4671733..4671873 - 141 WP_004147370.1 hypothetical protein -
GSU00_RS22845 4671894..4672364 + 471 WP_002892026.1 YlaC family protein -
GSU00_RS22850 4672339..4673064 - 726 Protein_4527 PLP-dependent aminotransferase family protein -
GSU00_RS22855 4673132..4674324 + 1193 WP_085955245.1 IS3-like element ISKpn18 family transposase -
GSU00_RS22860 4674365..4675096 - 732 Protein_4529 PLP-dependent aminotransferase family protein -
GSU00_RS22865 4675197..4675895 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GSU00_RS22870 4675892..4676032 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T145515 WP_002892050.1 NZ_CP047160:4670818-4671036 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T145515 NZ_CP062400:2650415-2650777 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT145515 WP_002892066.1 NZ_CP047160:4670417-4670791 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT145515 NZ_CP062400:2650248-2650418 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References