Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4184..4710 Replicon chromosome
Accession NZ_CP047160
Organism Klebsiella pneumoniae strain KP19-2029

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag GSU00_RS00035 Protein ID WP_000323025.1
Coordinates 4423..4710 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag GSU00_RS00030 Protein ID WP_000534858.1
Coordinates 4184..4423 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSU00_RS00005 182..1522 + 1341 WP_000589001.1 ISNCY family transposase -
GSU00_RS00010 1943..2254 + 312 Protein_1 transposase -
GSU00_RS00020 3505..3921 + 417 Protein_3 cation-efflux pump -
GSU00_RS00030 4184..4423 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
GSU00_RS00035 4423..4710 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GSU00_RS00040 4782..4940 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
GSU00_RS27825 5543..6517 + 975 WP_004181899.1 hypothetical protein -
GSU00_RS00055 6715..7092 - 378 WP_004181901.1 hypothetical protein -
GSU00_RS00060 7782..8849 + 1068 WP_004181903.1 hypothetical protein -
GSU00_RS00065 9005..9352 + 348 WP_004181904.1 hypothetical protein -
GSU00_RS00070 9431..9664 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T145498 WP_000323025.1 NZ_CP047160:4423-4710 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T145498 NZ_CP062398:c2031328-2030966 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT145498 WP_000534858.1 NZ_CP047160:4184-4423 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT145498 NZ_CP062398:c2031495-2031325 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References