Detailed information of TA system TA145495

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 2314702..2315509
• Replicon: chromosome
• Accession: NZ_CP047158
• Organism: Anoxybacillus sp. PDR2

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: GRQ40_RS11080
• Protein ID: WP_066150379.1
• Coordinates: 2315099..2315509 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: GRQ40_RS11075
• Protein ID: WP_139788144.1
• Coordinates: 2314702..2315109 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRQ40_RS11040	2310570..2310815	-	246	Protein_2124	DDE-type integrase/transposase/recombinase	-
GRQ40_RS11045	2310799..2311110	-	312	WP_156450552.1	DDE-type integrase/transposase/recombinase	-
GRQ40_RS11050	2311127..2311249	-	123	WP_159719990.1	IS3 family transposase	-
GRQ40_RS11055	2311271..2311402	-	132	WP_159719991.1	helix-turn-helix domain-containing protein	-
GRQ40_RS11060	2311411..2311706	-	296	Protein_2128	helix-turn-helix domain-containing protein	-
GRQ40_RS11065	2312011..2313738	-	1728	WP_159719992.1	DNA-binding protein	-
GRQ40_RS11070	2314054..2314343	-	290	Protein_2130	transposase	-
GRQ40_RS11075	2314702..2315109	+	408	WP_139788144.1	nucleotidyltransferase domain-containing protein	Antitoxin
GRQ40_RS11080	2315099..2315509	+	411	WP_066150379.1	DUF86 domain-containing protein	Toxin
GRQ40_RS11085	2317567..2318355	-	789	WP_159719993.1	5-deoxy-glucuronate isomerase	-
GRQ40_RS11090	2318372..2319208	-	837	WP_159719994.1	class II aldolase	-
GRQ40_RS11095	2319222..2320118	-	897	WP_159719995.1	myo-inosose-2 dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (14-131)

Antitoxin

• Polymerase beta, nucleotidyltransferase (9-99)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15831.39 Da
• Isoelectric Point: 7.4333

>T145495 WP_066150379.1 NZ_CP047158:2315099-2315509 [Anoxybacillus sp. PDR2]
MKNDVILNKISVIERCIKRIHEEYENNPKNLENYTKQDSMILNLQRACEASIGLAMHMVAQKKLGLPQNSRDAFSLLEQH
GIITPFLSQKMKAMVGFRNIAVHDYQEINLTILQKILDHHLTDFTEFTKAILFYEQ

Nucleotide

• Length: 411 bp

>T145495 NZ_CP062396:c5141-4965 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15669.76 Da
• Isoelectric Point: 4.6889

>AT145495 WP_139788144.1 NZ_CP047158:2314702-2315109 [Anoxybacillus sp. PDR2]
MTEQIEPIIIEVLIETVSPYLIYLFGSTVTGHVHQDSDIDIAFLSDQKQLDHYERFMVAQELASRLHRDVDLVDLKQAST
VFQAQVVSNGKVIYCTNEQKKAEYEWRALKMYAKLNEERTEILRNINESGSVYEK

Nucleotide

• Length: 408 bp

>AT145495 NZ_CP062396:4834-4975 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT