Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 326585..327221 Replicon chromosome
Accession NZ_CP047158
Organism Anoxybacillus sp. PDR2

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GRQ40_RS01655 Protein ID WP_003253417.1
Coordinates 326871..327221 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A160FEC9
Locus tag GRQ40_RS01650 Protein ID WP_044741999.1
Coordinates 326585..326866 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRQ40_RS01630 322799..323401 - 603 WP_066148998.1 rhomboid family intramembrane serine protease -
GRQ40_RS01635 323607..323969 + 363 WP_044742002.1 holo-ACP synthase -
GRQ40_RS01640 324060..325073 + 1014 WP_044742001.1 outer membrane lipoprotein carrier protein LolA -
GRQ40_RS01645 325277..326446 + 1170 WP_044742000.1 alanine racemase -
GRQ40_RS01650 326585..326866 + 282 WP_044741999.1 hypothetical protein Antitoxin
GRQ40_RS01655 326871..327221 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GRQ40_RS01660 327350..329515 + 2166 WP_066149000.1 RNA-binding transcriptional accessory protein -
GRQ40_RS01665 329767..329892 - 126 WP_139788175.1 cortex morphogenetic protein CmpA -
GRQ40_RS01670 329976..330452 + 477 WP_159719246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T145494 WP_003253417.1 NZ_CP047158:326871-327221 [Anoxybacillus sp. PDR2]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T145494 NZ_CP062395:2722740-2723066 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAAATTTAATGTGTGATTTAAAGATATTGAAAGAAAAGTTTGAGGATTTAAAGGATAATCATGG
CTCGCATTTTGAAGATTTATATATACATGAGCCAAATCATACCTTAAATAAAGTCGATGTTATTAAAGAAGGGCTTTCAT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10644.18 Da        Isoelectric Point: 7.2025

>AT145494 WP_044741999.1 NZ_CP047158:326585-326866 [Anoxybacillus sp. PDR2]
MSESSATTEIVVRLPQALLTELDGLVKQENGNRNDLIYQATKMYIRERKKRHIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT145494 NZ_CP062395:2722528-2722737 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A160FEC9

References