Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3652172..3652794 Replicon chromosome
Accession NZ_CP047156
Organism Epidermidibacterium keratini strain EPI-7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EK0264_RS17535 Protein ID WP_159547022.1
Coordinates 3652378..3652794 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EK0264_RS17530 Protein ID WP_159547021.1
Coordinates 3652172..3652381 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK0264_RS17505 3647623..3648972 + 1350 WP_159547645.1 insulinase family protein -
EK0264_RS17510 3649106..3649858 + 753 WP_192933049.1 4-hydroxy-tetrahydrodipicolinate reductase -
EK0264_RS17515 3649863..3650756 - 894 WP_159547019.1 SDR family oxidoreductase -
EK0264_RS17520 3650816..3651490 - 675 WP_159547647.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
EK0264_RS17525 3651513..3652091 - 579 WP_159547020.1 GNAT family N-acetyltransferase -
EK0264_RS17530 3652172..3652381 + 210 WP_159547021.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EK0264_RS17535 3652378..3652794 + 417 WP_159547022.1 PIN domain nuclease Toxin
EK0264_RS17540 3652878..3654080 + 1203 WP_159547648.1 winged helix DNA-binding domain-containing protein -
EK0264_RS17545 3654070..3654351 - 282 WP_159547023.1 muconolactone Delta-isomerase -
EK0264_RS17550 3654383..3655246 - 864 WP_159547024.1 catechol 1,2-dioxygenase -
EK0264_RS17555 3655314..3656417 - 1104 WP_159547025.1 enolase -
EK0264_RS17560 3656414..3657328 - 915 WP_159547026.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3524995..3683521 158526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-38)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14931.95 Da        Isoelectric Point: 5.9781

>T145491 WP_159547022.1 NZ_CP047156:3652378-3652794 [Epidermidibacterium keratini]
VSALVDTSVWVEFLRGTQSAAADYVRHEVGRNLATCEPVMMELLAGLSAGDRTARVERMLLSQTWLRIDPHLDYRGAVDV
FHATRATGHAPRGLADCLIAAIALRAGVEVAHRDTDYEYIAAATGLATIDLRERTAAG

Download         Length: 417 bp

>T145491 NZ_CP062395:2337209-2337475 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7784.89 Da        Isoelectric Point: 4.1546

>AT145491 WP_159547021.1 NZ_CP047156:3652172-3652381 [Epidermidibacterium keratini]
MTRTNIEIDDALIAEVMDRFSLSTKREAVDFALRRLVGPVMTRQEMLMLEGSGWEGDLDELRGDPVTSV

Download         Length: 210 bp

>AT145491 NZ_CP062395:2336958-2337209 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References