Detailed information of TA system TA145490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3433416..3434095
• Replicon: chromosome
• Accession: NZ_CP047156
• Organism: Epidermidibacterium keratini strain EPI-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EK0264_RS16465
• Protein ID: WP_159546855.1
• Coordinates: 3433664..3434095 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EK0264_RS16460
• Protein ID: WP_159546854.1
• Coordinates: 3433416..3433667 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EK0264_RS16440	3429373..3431190	+	1818	WP_159546851.1	ATP-binding cassette domain-containing protein	-
EK0264_RS16445	3431256..3431651	+	396	WP_159546852.1	SRPBCC family protein	-
EK0264_RS16450	3431701..3432510	+	810	WP_159546853.1	enoyl-CoA hydratase/isomerase family protein	-
EK0264_RS16455	3432641..3433300	-	660	WP_159547619.1	endonuclease NucS	-
EK0264_RS16460	3433416..3433667	+	252	WP_159546854.1	antitoxin	Antitoxin
EK0264_RS16465	3433664..3434095	+	432	WP_159546855.1	type II toxin-antitoxin system VapC family toxin	Toxin
EK0264_RS16470	3434157..3435659	+	1503	WP_159546856.1	aldehyde dehydrogenase family protein	-
EK0264_RS16475	3435640..3436698	-	1059	WP_159547620.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
EK0264_RS16480	3437049..3438833	+	1785	WP_159546857.1	3-hydroxyacyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15334.34 Da
• Isoelectric Point: 4.8053

>T145490 WP_159546855.1 NZ_CP047156:3433664-3434095 [Epidermidibacterium keratini]
VKVVDANVLLYAVNSDASHHDASRAWLDKSLNGADTVGFSWLAMTAFLRLVTKVGLFPNAMSVDEALDQVRDWLDAPGAQ
VVEPTQQHLAVLQRLLTAVGAGGNLVSDAHLAAIALEHRAGVVSYDADFARFGVSWARPDDLL

Nucleotide

• Length: 432 bp

>T145490 NZ_CP062395:2280411-2280677 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9295.59 Da
• Isoelectric Point: 8.9715

>AT145490 WP_159546854.1 NZ_CP047156:3433416-3433667 [Epidermidibacterium keratini]
MRTTVTLDPDVESLLRRLMQRRGISFKQALNDAVRVGAADGPREEFQTTTRGLGVPTVNLDRALQIAADLEDDELVRRMR
SGK

Nucleotide

• Length: 252 bp

>AT145490 NZ_CP062395:2280154-2280411 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA