Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3433416..3434095 Replicon chromosome
Accession NZ_CP047156
Organism Epidermidibacterium keratini strain EPI-7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EK0264_RS16465 Protein ID WP_159546855.1
Coordinates 3433664..3434095 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EK0264_RS16460 Protein ID WP_159546854.1
Coordinates 3433416..3433667 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK0264_RS16440 3429373..3431190 + 1818 WP_159546851.1 ATP-binding cassette domain-containing protein -
EK0264_RS16445 3431256..3431651 + 396 WP_159546852.1 SRPBCC family protein -
EK0264_RS16450 3431701..3432510 + 810 WP_159546853.1 enoyl-CoA hydratase/isomerase family protein -
EK0264_RS16455 3432641..3433300 - 660 WP_159547619.1 endonuclease NucS -
EK0264_RS16460 3433416..3433667 + 252 WP_159546854.1 antitoxin Antitoxin
EK0264_RS16465 3433664..3434095 + 432 WP_159546855.1 type II toxin-antitoxin system VapC family toxin Toxin
EK0264_RS16470 3434157..3435659 + 1503 WP_159546856.1 aldehyde dehydrogenase family protein -
EK0264_RS16475 3435640..3436698 - 1059 WP_159547620.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
EK0264_RS16480 3437049..3438833 + 1785 WP_159546857.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15334.34 Da        Isoelectric Point: 4.8053

>T145490 WP_159546855.1 NZ_CP047156:3433664-3434095 [Epidermidibacterium keratini]
VKVVDANVLLYAVNSDASHHDASRAWLDKSLNGADTVGFSWLAMTAFLRLVTKVGLFPNAMSVDEALDQVRDWLDAPGAQ
VVEPTQQHLAVLQRLLTAVGAGGNLVSDAHLAAIALEHRAGVVSYDADFARFGVSWARPDDLL

Download         Length: 432 bp

>T145490 NZ_CP062395:2280411-2280677 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9295.59 Da        Isoelectric Point: 8.9715

>AT145490 WP_159546854.1 NZ_CP047156:3433416-3433667 [Epidermidibacterium keratini]
MRTTVTLDPDVESLLRRLMQRRGISFKQALNDAVRVGAADGPREEFQTTTRGLGVPTVNLDRALQIAADLEDDELVRRMR
SGK

Download         Length: 252 bp

>AT145490 NZ_CP062395:2280154-2280411 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References