Detailed information of TA system TA145489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-StbC
• Location: 3355211..3355836
• Replicon: chromosome
• Accession: NZ_CP047156
• Organism: Epidermidibacterium keratini strain EPI-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EK0264_RS16055
• Protein ID: WP_159546788.1
• Coordinates: 3355435..3355836 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EK0264_RS16050
• Protein ID: WP_159546787.1
• Coordinates: 3355211..3355438 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EK0264_RS16030	3351073..3351597	-	525	WP_192933039.1	hypothetical protein	-
EK0264_RS16035	3351723..3352859	+	1137	WP_159547607.1	FUSC family protein	-
EK0264_RS16040	3352866..3353960	-	1095	WP_159546785.1	helix-turn-helix domain-containing protein	-
EK0264_RS16045	3354016..3355155	+	1140	WP_159546786.1	citrate synthase/methylcitrate synthase	-
EK0264_RS16050	3355211..3355438	+	228	WP_159546787.1	hypothetical protein	Antitoxin
EK0264_RS16055	3355435..3355836	+	402	WP_159546788.1	type II toxin-antitoxin system VapC family toxin	Toxin
EK0264_RS16060	3355876..3357069	+	1194	WP_159546789.1	L-2-hydroxyglutarate oxidase	-
EK0264_RS16065	3357069..3357767	+	699	WP_159546790.1	VTT domain-containing protein	-
EK0264_RS16070	3357764..3358729	+	966	WP_159546791.1	threo-3-hydroxy-L-aspartate ammonia-lyase	-
EK0264_RS16075	3358730..3359353	-	624	WP_159546792.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
EK0264_RS16080	3359387..3360214	-	828	WP_159546793.1	histidinol-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13937.12 Da
• Isoelectric Point: 4.8014

>T145489 WP_159546788.1 NZ_CP047156:3355435-3355836 [Epidermidibacterium keratini]
VIVLDASAAVEWLLGRPAAGSIAARLADPDTAIHAPSLVGVEVTSALRGLVLARHATAERASAALSDLMGLDISLHDPTP
LLPRVWALRDNLTVYDAVYVALAEILDATLLTTDARIARAMRPDAAVDVLVAR

Nucleotide

• Length: 402 bp

>T145489 NZ_CP062395:1197177-1197365 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8324.49 Da
• Isoelectric Point: 11.0140

>AT145489 WP_159546787.1 NZ_CP047156:3355211-3355438 [Epidermidibacterium keratini]
VTMIQIRNVPDDVHRRLKARAAMEGVSLSELALSELTRSLDRPTRRELLDLVASREQVRGGPSSATLVERARDAS

Nucleotide

• Length: 228 bp

>AT145489 NZ_CP062395:1196888-1197148 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA