Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-StbC
Location 3355211..3355836 Replicon chromosome
Accession NZ_CP047156
Organism Epidermidibacterium keratini strain EPI-7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EK0264_RS16055 Protein ID WP_159546788.1
Coordinates 3355435..3355836 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EK0264_RS16050 Protein ID WP_159546787.1
Coordinates 3355211..3355438 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK0264_RS16030 3351073..3351597 - 525 WP_192933039.1 hypothetical protein -
EK0264_RS16035 3351723..3352859 + 1137 WP_159547607.1 FUSC family protein -
EK0264_RS16040 3352866..3353960 - 1095 WP_159546785.1 helix-turn-helix domain-containing protein -
EK0264_RS16045 3354016..3355155 + 1140 WP_159546786.1 citrate synthase/methylcitrate synthase -
EK0264_RS16050 3355211..3355438 + 228 WP_159546787.1 hypothetical protein Antitoxin
EK0264_RS16055 3355435..3355836 + 402 WP_159546788.1 type II toxin-antitoxin system VapC family toxin Toxin
EK0264_RS16060 3355876..3357069 + 1194 WP_159546789.1 L-2-hydroxyglutarate oxidase -
EK0264_RS16065 3357069..3357767 + 699 WP_159546790.1 VTT domain-containing protein -
EK0264_RS16070 3357764..3358729 + 966 WP_159546791.1 threo-3-hydroxy-L-aspartate ammonia-lyase -
EK0264_RS16075 3358730..3359353 - 624 WP_159546792.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
EK0264_RS16080 3359387..3360214 - 828 WP_159546793.1 histidinol-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.12 Da        Isoelectric Point: 4.8014

>T145489 WP_159546788.1 NZ_CP047156:3355435-3355836 [Epidermidibacterium keratini]
VIVLDASAAVEWLLGRPAAGSIAARLADPDTAIHAPSLVGVEVTSALRGLVLARHATAERASAALSDLMGLDISLHDPTP
LLPRVWALRDNLTVYDAVYVALAEILDATLLTTDARIARAMRPDAAVDVLVAR

Download         Length: 402 bp

>T145489 NZ_CP062395:1197177-1197365 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8324.49 Da        Isoelectric Point: 11.0140

>AT145489 WP_159546787.1 NZ_CP047156:3355211-3355438 [Epidermidibacterium keratini]
VTMIQIRNVPDDVHRRLKARAAMEGVSLSELALSELTRSLDRPTRRELLDLVASREQVRGGPSSATLVERARDAS

Download         Length: 228 bp

>AT145489 NZ_CP062395:1196888-1197148 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References