145488

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2733282..2733871 Replicon chromosome
Accession NZ_CP047156
Organism Epidermidibacterium keratini strain EPI-7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EK0264_RS13145 Protein ID WP_159546280.1
Coordinates 2733282..2733629 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EK0264_RS13150 Protein ID WP_159546281.1
Coordinates 2733623..2733871 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK0264_RS13125 2728717..2729637 - 921 WP_159546277.1 hypothetical protein -
EK0264_RS13130 2729965..2730282 + 318 WP_159547547.1 MarR family transcriptional regulator -
EK0264_RS13135 2730279..2731622 + 1344 WP_159546278.1 MFS transporter -
EK0264_RS13140 2732127..2733272 + 1146 WP_159546279.1 RNA methyltransferase -
EK0264_RS13145 2733282..2733629 - 348 WP_159546280.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EK0264_RS13150 2733623..2733871 - 249 WP_159546281.1 CopG family transcriptional regulator Antitoxin
EK0264_RS13155 2733978..2735306 + 1329 WP_159546282.1 sensor histidine kinase -
EK0264_RS13160 2735303..2735974 + 672 WP_159546283.1 response regulator transcription factor -
EK0264_RS13165 2736056..2736967 + 912 WP_159546284.1 ATP-binding cassette domain-containing protein -
EK0264_RS13170 2736967..2738097 + 1131 WP_159546285.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12009.76 Da        Isoelectric Point: 5.7949

>T145488 WP_159546280.1 NZ_CP047156:c2733629-2733282 [Epidermidibacterium keratini]
VVSRGEVYWCELGEPSGSAPAMRRPVVVIQAGGFNRSRIATTVVAVLTSNTALAAMPGNVFLPADVSGLPKDSVVNVSAL
ATVDRRDLDPRAAGEVPAHLMRDVDAGLRTVLDLS

Download         Length: 348 bp

>T145488 NZ_CP062395:110497-110649 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACGAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8886.74 Da        Isoelectric Point: 4.5388

>AT145488 WP_159546281.1 NZ_CP047156:c2733871-2733623 [Epidermidibacterium keratini]
MKTAISVPDETFERIERVAKKHGINRSQFYATAAAKYADELESNELTAAINAVADAVNDDDSTTAARAAANRTLSDPITS
QW

Download         Length: 249 bp

>AT145488 NZ_CP062395:109873-110472 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References