Detailed information of TA system TA145487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 503654..504327
• Replicon: chromosome
• Accession: NZ_CP047156
• Organism: Epidermidibacterium keratini strain EPI-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EK0264_RS02460
• Protein ID: WP_159542565.1
• Coordinates: 503654..504091 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EK0264_RS02465
• Protein ID: WP_159542567.1
• Coordinates: 504088..504327 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EK0264_RS02440	498967..500340	+	1374	WP_159542560.1	NADP-dependent succinic semialdehyde dehydrogenase	-
EK0264_RS02445	500416..502068	-	1653	WP_159542561.1	sodium:solute symporter	-
EK0264_RS02450	502073..502357	-	285	WP_159542562.1	DUF3311 domain-containing protein	-
EK0264_RS02455	502508..503629	-	1122	WP_159542563.1	Nif3-like dinuclear metal center hexameric protein	-
EK0264_RS02460	503654..504091	-	438	WP_159542565.1	type II toxin-antitoxin system VapC family toxin	Toxin
EK0264_RS02465	504088..504327	-	240	WP_159542567.1	plasmid stability protein	Antitoxin
EK0264_RS02470	504376..505920	-	1545	WP_159542569.1	acyl-CoA dehydrogenase family protein	-
EK0264_RS02475	506032..507240	-	1209	WP_159542571.1	acyl-CoA dehydrogenase family protein	-
EK0264_RS02480	507244..508935	-	1692	WP_159542573.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15716.92 Da
• Isoelectric Point: 4.4349

>T145487 WP_159542565.1 NZ_CP047156:c504091-503654 [Epidermidibacterium keratini]
VIIVDTNVISEPLRPRPAEAVLAWLDDQAIETVYLTTITLAEIRFGIASLPAGKRQRTLRTRFDDEMLELFGDRILSFDR
VAAEEYGDLRARAVSRGLAIGDLDAMIAAIAAARGFAVATRDVRPFIDAGIQVVNPFESGEGGGT

Nucleotide

• Length: 438 bp

>T145487 NZ_CP062393:2714822-2715184 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8460.54 Da
• Isoelectric Point: 11.3253

>AT145487 WP_159542567.1 NZ_CP047156:c504327-504088 [Epidermidibacterium keratini]
MAAITVRNLSDSTHRALKSRAKSHGRSTEAEVRAILDDAVAVQKQGGLGSRLREIGRAVGGVDLDIDRSRQGRPPVDLT

Nucleotide

• Length: 240 bp

>AT145487 NZ_CP062393:2714655-2714825 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA