Detailed information of TA system TA145485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 358665..360238
• Replicon: chromosome
• Accession: NZ_CP047155
• Organism: Aeromonas veronii strain AVNIH1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GRF56_RS01740
• Protein ID: WP_159142781.1
• Coordinates: 358919..360238 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GRF56_RS01735
• Protein ID: WP_017410478.1
• Coordinates: 358665..358919 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRF56_RS01725	356834..357457	-	624	WP_115522767.1	recombinase family protein	-
GRF56_RS01730	358067..358495	+	429	WP_128816792.1	DUF86 domain-containing protein	-
GRF56_RS01735	358665..358919	+	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
GRF56_RS01740	358919..360238	+	1320	WP_159142781.1	type II toxin-antitoxin system HipA family toxin	Toxin
GRF56_RS01745	360660..362642	-	1983	WP_159142782.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
GRF56_RS01750	362639..363523	-	885	WP_159144516.1	ABC transporter substrate-binding protein	-
GRF56_RS01755	363558..364322	-	765	WP_159142783.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	floR / tet(A)	-	320312..360238	39926

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49585.54 Da
• Isoelectric Point: 6.6626

>T145485 WP_159142781.1 NZ_CP047155:358919-360238 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDETYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPQCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEHDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T145485 NZ_CP062393:2637763-2637867 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT145485 WP_017410478.1 NZ_CP047155:358665-358919 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT145485 NZ_CP062393:c2638026-2637862 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT