Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/YoeB-RelB |
Location | 2008652..2009181 | Replicon | chromosome |
Accession | NZ_CP047142 | ||
Organism | Lactobacillus crispatus strain C25 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | A0A854ZB67 |
Locus tag | GSR61_RS09940 | Protein ID | WP_025006274.1 |
Coordinates | 2008652..2008909 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | V5E284 |
Locus tag | GSR61_RS09945 | Protein ID | WP_013087009.1 |
Coordinates | 2008906..2009181 (-) | Length | 92 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GSR61_RS09915 | 2003734..2004507 | - | 774 | WP_065991111.1 | tyrosine-protein phosphatase | - |
GSR61_RS09920 | 2004563..2006062 | - | 1500 | WP_057727002.1 | glycerol kinase GlpK | - |
GSR61_RS09925 | 2006187..2007002 | + | 816 | WP_013087004.1 | bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase | - |
GSR61_RS09935 | 2007721..2008550 | - | 830 | Protein_1905 | helix-turn-helix transcriptional regulator | - |
GSR61_RS09940 | 2008652..2008909 | - | 258 | WP_025006274.1 | Txe/YoeB family addiction module toxin | Toxin |
GSR61_RS09945 | 2008906..2009181 | - | 276 | WP_013087009.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GSR61_RS09950 | 2009277..2009408 | - | 132 | WP_065991109.1 | MFS transporter | - |
GSR61_RS09955 | 2009520..2009930 | + | 411 | WP_065991107.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
GSR61_RS09960 | 2009936..2010229 | + | 294 | WP_013087011.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
GSR61_RS09965 | 2010299..2010985 | + | 687 | WP_065991105.1 | cobalamin biosynthesis protein CobQ | - |
GSR61_RS09970 | 2011030..2011515 | - | 486 | WP_065991103.1 | C40 family peptidase | - |
GSR61_RS09975 | 2011710..2012060 | + | 351 | WP_065991101.1 | ABC transporter substrate-binding protein | - |
GSR61_RS09980 | 2012458..2012739 | + | 282 | WP_065991097.1 | hypothetical protein | - |
GSR61_RS09985 | 2012760..2013689 | - | 930 | WP_065991095.1 | DMT family transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10219.64 Da Isoelectric Point: 8.9406
>T145484 WP_025006274.1 NZ_CP047142:c2008909-2008652 [Lactobacillus crispatus]
MIVAWTDDGWNDYVYWYDDGDYKKVSRINDLVKDMKRHPFTGIGKPEPLKRNLSGLWSRRIDSKNRIVYDCHKSMITIYS
CKDHY
MIVAWTDDGWNDYVYWYDDGDYKKVSRINDLVKDMKRHPFTGIGKPEPLKRNLSGLWSRRIDSKNRIVYDCHKSMITIYS
CKDHY
Download Length: 258 bp
>T145484 NZ_CP062393:2372703-2372969 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10597.82 Da Isoelectric Point: 4.5716
>AT145484 WP_013087009.1 NZ_CP047142:c2009181-2008906 [Lactobacillus crispatus]
MDAVNYSNFRKNLKHYFKQVNDDSEPLIVTNKEPEDNVVVLGKEDYDALVETLEIQSNQYLMDKIERGRKQVSEGTIKQH
ELIDPEQVTKS
MDAVNYSNFRKNLKHYFKQVNDDSEPLIVTNKEPEDNVVVLGKEDYDALVETLEIQSNQYLMDKIERGRKQVSEGTIKQH
ELIDPEQVTKS
Download Length: 276 bp
>AT145484 NZ_CP062393:2372452-2372703 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A854ZB67 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V5E284 |