Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4970922..4971487 Replicon chromosome
Accession NZ_CP047140
Organism Streptomyces sp. Tu 2975

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GLX30_RS22005 Protein ID WP_159691607.1
Coordinates 4971119..4971487 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GLX30_RS22000 Protein ID WP_159691605.1
Coordinates 4970922..4971119 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLX30_RS21980 4967413..4968336 - 924 WP_159691601.1 serine/threonine protein kinase -
GLX30_RS21985 4968534..4968914 + 381 Protein_4344 DUF1269 domain-containing protein -
GLX30_RS21995 4969231..4970889 + 1659 WP_159691603.1 MFS transporter -
GLX30_RS22000 4970922..4971119 + 198 WP_159691605.1 Arc family DNA-binding protein Antitoxin
GLX30_RS22005 4971119..4971487 + 369 WP_159691607.1 Fic family protein Toxin
GLX30_RS22010 4971636..4973420 + 1785 WP_159691609.1 DEAD/DEAH box helicase -
GLX30_RS22015 4973786..4974427 + 642 WP_159691611.1 helix-turn-helix domain-containing protein -
GLX30_RS22020 4974513..4975301 + 789 WP_159691613.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(8-80)

Antitoxin

Arc-like DNA binding domain

(5-33)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13682.66 Da        Isoelectric Point: 4.8382

>T145483 WP_159691607.1 NZ_CP047140:4971119-4971487 [Streptomyces sp. Tu 2975]
MNYLTLPELLKLADRLGAEEVRDYGLLDSALARPQSSVFGQDAYPDIWQKAAALMESLARNHALVDGNKRIAWYATWVFL
HMNGHPLSPGFDVDEAEQFVLNVCQGLLDVPKIAEQLPRFAK

Download         Length: 369 bp

>T145483 NZ_CP062393:2347432-2347539 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7351.17 Da        Isoelectric Point: 5.0762

>AT145483 WP_159691605.1 NZ_CP047140:4970922-4971119 [Streptomyces sp. Tu 2975]
MAGLNLRFTEEELNALRERAEAEGRSMQSFAHDAVITAINEHSRLFNEAADHVLKASEELNRRLA

Download         Length: 198 bp

>AT145483 NZ_CP062393:c2347616-2347556 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References