Detailed information of TA system TA145481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2022901..2023378
• Replicon: chromosome
• Accession: NZ_CP047134
• Organism: Xylella fastidiosa subsp. multiplex strain IVIA5901

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: DVT08_RS09145
• Protein ID: WP_004087087.1
• Coordinates: 2023112..2023378 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: DVT08_RS09140
• Protein ID: WP_004091377.1
• Coordinates: 2022901..2023128 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVT08_RS09100	2017992..2019137	-	1146	WP_128283772.1	baseplate J/gp47 family protein	-
DVT08_RS09105	2019240..2019536	+	297	WP_004085590.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DVT08_RS09110	2019539..2019832	+	294	WP_004085592.1	putative addiction module antidote protein	-
DVT08_RS09115	2019888..2020241	-	354	WP_004084998.1	hypothetical protein	-
DVT08_RS09120	2020238..2020879	-	642	WP_012382583.1	hypothetical protein	-
DVT08_RS09125	2020876..2021706	-	831	WP_004085594.1	hypothetical protein	-
DVT08_RS09130	2021703..2022020	-	318	WP_004085001.1	hypothetical protein	-
DVT08_RS09135	2022020..2022790	-	771	WP_128283773.1	hypothetical protein	-
DVT08_RS09140	2022901..2023128	+	228	WP_004091377.1	hypothetical protein	Antitoxin
DVT08_RS09145	2023112..2023378	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVT08_RS09150	2023389..2025278	-	1890	WP_187120430.1	hypothetical protein	-
DVT08_RS09155	2025426..2025848	-	423	WP_128283793.1	hypothetical protein	-
DVT08_RS09160	2025845..2026281	-	437	Protein_1787	DUF3277 family protein	-
DVT08_RS09165	2026291..2027787	-	1497	WP_128283792.1	DUF3383 domain-containing protein	-
DVT08_RS09170	2027788..2028320	-	533	Protein_1789	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2005971..2079189	73218

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10207.80 Da
• Isoelectric Point: 10.3398

>T145481 WP_004087087.1 NZ_CP047134:2023112-2023378 [Xylella fastidiosa subsp. multiplex]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCDIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T145481 NZ_CP062393:1210625-1210813 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT145481 WP_004091377.1 NZ_CP047134:2022901-2023128 [Xylella fastidiosa subsp. multiplex]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT145481 NZ_CP062393:1210336-1210596 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7G7TPD2