Detailed information of TA system TA145480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 2019240..2019832
• Replicon: chromosome
• Accession: NZ_CP047134
• Organism: Xylella fastidiosa subsp. multiplex strain IVIA5901

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A060HCK8
• Locus tag: DVT08_RS09105
• Protein ID: WP_004085590.1
• Coordinates: 2019240..2019536 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: DVT08_RS09110
• Protein ID: WP_004085592.1
• Coordinates: 2019539..2019832 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVT08_RS09085	2014903..2015808	-	906	WP_038211728.1	peptidase	-
DVT08_RS09090	2016268..2017431	-	1164	WP_187120394.1	phage tail protein	-
DVT08_RS09095	2017435..2017995	-	561	WP_004084996.1	DUF2612 domain-containing protein	-
DVT08_RS09100	2017992..2019137	-	1146	WP_128283772.1	baseplate J/gp47 family protein	-
DVT08_RS09105	2019240..2019536	+	297	WP_004085590.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVT08_RS09110	2019539..2019832	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
DVT08_RS09115	2019888..2020241	-	354	WP_004084998.1	hypothetical protein	-
DVT08_RS09120	2020238..2020879	-	642	WP_012382583.1	hypothetical protein	-
DVT08_RS09125	2020876..2021706	-	831	WP_004085594.1	hypothetical protein	-
DVT08_RS09130	2021703..2022020	-	318	WP_004085001.1	hypothetical protein	-
DVT08_RS09135	2022020..2022790	-	771	WP_128283773.1	hypothetical protein	-
DVT08_RS09140	2022901..2023128	+	228	WP_004091377.1	hypothetical protein	-
DVT08_RS09145	2023112..2023378	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2005971..2079189	73218

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11169.70 Da
• Isoelectric Point: 10.0610

>T145480 WP_004085590.1 NZ_CP047134:2019240-2019536 [Xylella fastidiosa subsp. multiplex]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T145480 NZ_CP047134:2019240-2019536 [Xylella fastidiosa subsp. multiplex]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCGCGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCGGCGTGGCGACACGATCTACTTGCTGCTTTGCGGCGGTGACAAAGGA
TCACAAGCGCGCGACATCAAGACTGCGCTGCACCTGTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT145480 WP_004085592.1 NZ_CP047134:2019539-2019832 [Xylella fastidiosa subsp. multiplex]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT145480 NZ_CP047134:2019539-2019832 [Xylella fastidiosa subsp. multiplex]
ATGACCGAGAAACTGACGAGCTACGATCCAGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCTGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTGGCC
GTGATGAAGGCGCTCGGGATCGAGCTGTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A060HCK8