Detailed information of TA system TA145478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1334759..1335281
• Replicon: chromosome
• Accession: NZ_CP047134
• Organism: Xylella fastidiosa subsp. multiplex strain IVIA5901

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DVT08_RS05990
• Protein ID: WP_004085905.1
• Coordinates: 1334994..1335281 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A060HDF9
• Locus tag: DVT08_RS05985
• Protein ID: WP_004085758.1
• Coordinates: 1334759..1335001 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVT08_RS05955	1330168..1330350	+	183	WP_027700467.1	hypothetical protein	-
DVT08_RS05960	1330634..1331560	-	927	WP_004085766.1	Grx4 family monothiol glutaredoxin	-
DVT08_RS05965	1331626..1332402	+	777	WP_027700469.1	polysaccharide deacetylase family protein	-
DVT08_RS05970	1333047..1333238	-	192	WP_021358405.1	hypothetical protein	-
DVT08_RS05975	1333656..1334075	-	420	WP_004085763.1	putative toxin-antitoxin system toxin component, PIN family	-
DVT08_RS05980	1334075..1334314	-	240	WP_004085761.1	ribbon-helix-helix domain-containing protein	-
DVT08_RS05985	1334759..1335001	+	243	WP_004085758.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
DVT08_RS05990	1334994..1335281	+	288	WP_004085905.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVT08_RS05995	1335369..1335935	+	567	WP_004085755.1	recombinase family protein	-
DVT08_RS06000	1335988..1337185	-	1198	Protein_1161	IS200/IS605 family element transposase accessory protein TnpB	-
DVT08_RS06005	1337179..1337805	-	627	WP_038230952.1	IS607 family transposase	-
DVT08_RS06010	1337839..1337964	-	126	Protein_1163	DNA adenine methylase	-
DVT08_RS06015	1337934..1338203	-	270	Protein_1164	hypothetical protein	-
DVT08_RS06020	1338200..1338895	-	696	WP_004086766.1	hypothetical protein	-
DVT08_RS06025	1338971..1339390	-	420	WP_187120380.1	hypothetical protein	-
DVT08_RS06030	1339394..1339906	-	513	Protein_1167	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1335369..1335935	566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11159.64 Da
• Isoelectric Point: 5.9570

>T145478 WP_004085905.1 NZ_CP047134:1334994-1335281 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Nucleotide

• Length: 288 bp

>T145478 NZ_CP062393:20011-20187 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8774.77 Da
• Isoelectric Point: 6.9881

>AT145478 WP_004085758.1 NZ_CP047134:1334759-1335001 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Nucleotide

• Length: 243 bp

>AT145478 NZ_CP062393:c20349-20175 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin

• AlphaFold DB: A0A060HDF9