Detailed information of TA system TA145476

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 753865..754619
• Replicon: chromosome
• Accession: NZ_CP047134
• Organism: Xylella fastidiosa subsp. multiplex strain IVIA5901

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DVT08_RS03260
• Protein ID: WP_004085397.1
• Coordinates: 753865..754350 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: DVT08_RS03265
• Protein ID: WP_004085396.1
• Coordinates: 754347..754619 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVT08_RS03250	750717..751523	+	807	WP_128283803.1	oxidoreductase	-
DVT08_RS03255	752557..753529	+	973	Protein_620	toprim domain-containing protein	-
DVT08_RS03260	753865..754350	-	486	WP_004085397.1	GNAT family N-acetyltransferase	Toxin
DVT08_RS03265	754347..754619	-	273	WP_004085396.1	DUF1778 domain-containing protein	Antitoxin
DVT08_RS03270	754971..755876	-	906	WP_004085395.1	AEC family transporter	-
DVT08_RS03275	755992..756611	+	620	Protein_624	IS607 family transposase	-
DVT08_RS03280	757079..758872	+	1794	WP_031345943.1	glycosyl hydrolase family 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (35-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-85)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17858.66 Da
• Isoelectric Point: 9.9283

>T145476 WP_004085397.1 NZ_CP047134:c754350-753865 [Xylella fastidiosa subsp. multiplex]
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRRALTNHLNGASRTFVVIDANQYVLGYYALAAGAVAHQEATRAIRRNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQSIAENAGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F

Nucleotide

• Length: 486 bp

>T145476 NZ_CP062390:2699916-2700278 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10264.77 Da
• Isoelectric Point: 5.0488

>AT145476 WP_004085396.1 NZ_CP047134:c754619-754347 [Xylella fastidiosa subsp. multiplex]
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLNAPQDTNPGLNRLMA
IKAPWSISNT

Nucleotide

• Length: 273 bp

>AT145476 NZ_CP062390:2699749-2699919 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA