Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 474433..475019 Replicon chromosome
Accession NZ_CP047134
Organism Xylella fastidiosa subsp. multiplex strain IVIA5901

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag DVT08_RS01970 Protein ID WP_004089517.1
Coordinates 474765..475019 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag DVT08_RS01965 Protein ID WP_004085025.1
Coordinates 474433..474768 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVT08_RS01935 471207..471782 - 576 WP_181008160.1 terminase small subunit -
DVT08_RS01940 471913..472137 - 225 WP_012337656.1 hypothetical protein -
DVT08_RS01945 472139..472600 - 462 WP_169709972.1 hypothetical protein -
DVT08_RS01950 472590..472919 - 330 WP_128283718.1 phage holin family protein -
DVT08_RS01955 472912..473412 - 501 WP_128382956.1 lysozyme -
DVT08_RS01960 473512..474243 - 732 WP_169709925.1 site-specific DNA-methyltransferase -
DVT08_RS01965 474433..474768 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DVT08_RS01970 474765..475019 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
DVT08_RS01975 475072..475794 - 723 WP_004085026.1 hypothetical protein -
DVT08_RS01980 476332..477540 + 1209 Protein_372 DNA polymerase -
DVT08_RS01985 477537..477815 + 279 WP_004085028.1 VRR-NUC domain-containing protein -
DVT08_RS01990 477817..478221 - 405 WP_004085029.1 hypothetical protein -
DVT08_RS01995 478306..479724 + 1419 WP_187120414.1 DEAD/DEAH box helicase -
DVT08_RS02000 479721..479885 + 165 WP_004086189.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 434819..483644 48825


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T145475 WP_004089517.1 NZ_CP047134:c475019-474765 [Xylella fastidiosa subsp. multiplex]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T145475 NZ_CP062390:2680311-2680520 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT145475 WP_004085025.1 NZ_CP047134:c474768-474433 [Xylella fastidiosa subsp. multiplex]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT145475 NZ_CP062390:2680006-2680299 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References