Detailed information of TA system TA145471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4145142..4145713
• Replicon: chromosome
• Accession: NZ_CP047130
• Organism: Colwellia sp. 20A7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GQS55_RS17840
• Protein ID: WP_159821758.1
• Coordinates: 4145420..4145713 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GQS55_RS17835
• Protein ID: WP_159821756.1
• Coordinates: 4145142..4145423 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQS55_RS17815	4140923..4141561	+	639	WP_159821753.1	hypothetical protein	-
GQS55_RS17820	4141671..4141973	+	303	WP_159821754.1	hypothetical protein	-
GQS55_RS17825	4142096..4143121	+	1026	WP_159817298.1	IS110 family transposase	-
GQS55_RS17830	4143802..4144956	-	1155	WP_159817300.1	IS110 family transposase	-
GQS55_RS17835	4145142..4145423	+	282	WP_159821756.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GQS55_RS17840	4145420..4145713	+	294	WP_159821758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GQS55_RS17845	4145826..4146851	+	1026	WP_159817298.1	IS110 family transposase	-
GQS55_RS17850	4147247..4147564	+	318	WP_159821760.1	type II toxin-antitoxin system MqsR family toxin	-
GQS55_RS17855	4147581..4148114	+	534	WP_159821762.1	type II toxin-antitoxin system MqsA family antitoxin	-
GQS55_RS17860	4148107..4148586	+	480	WP_159821764.1	hypothetical protein	-
GQS55_RS17865	4149023..4150177	-	1155	WP_159817300.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	4143802..4151808	8006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11084.82 Da
• Isoelectric Point: 5.1299

>T145471 WP_159821758.1 NZ_CP047130:4145420-4145713 [Colwellia sp. 20A7]
MKVVWSPLALDKLETTAQFIALDKPSAADKWVNDIFDRTELLGSQPELGREVPELLGSHYRELIFGNYRIIYKVGNEIKI
LTLRNSRQLLSLGDIEL

Nucleotide

• Length: 294 bp

>T145471 NZ_CP062390:2313630-2313896 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10312.71 Da
• Isoelectric Point: 5.8451

>AT145471 WP_159821756.1 NZ_CP047130:4145142-4145423 [Colwellia sp. 20A7]
MSRLHFDQDIQPLSDFRAGAASFIRQVNETRRPIVITQRGKGVAVVLDVAEYESMQEKIELLEEVQKAEAQISAGLGISN
SDARAQVLKSIRS

Nucleotide

• Length: 282 bp

>AT145471 NZ_CP062390:2313373-2313630 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA