Detailed information of TA system TA145470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 293708..294279
• Replicon: chromosome
• Accession: NZ_CP047129
• Organism: Bifidobacterium adolescentis strain ZJ2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F3K97_RS01135
• Protein ID: WP_003807675.1
• Coordinates: 293708..294007 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C2Z6P7
• Locus tag: F3K97_RS01140
• Protein ID: WP_034984155.1
• Coordinates: 294007..294279 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3K97_RS01125	290385..291113	+	729	WP_003807670.1	type 1 glutamine amidotransferase	-
F3K97_RS01130	291425..293611	+	2187	WP_159140452.1	ABC-F family ATP-binding cassette domain-containing protein	-
F3K97_RS01135	293708..294007	-	300	WP_003807675.1	type II toxin-antitoxin system YafQ family toxin	Toxin
F3K97_RS01140	294007..294279	-	273	WP_034984155.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F3K97_RS01145	294393..295202	-	810	WP_159140453.1	hypothetical protein	-
F3K97_RS01150	295386..295925	+	540	WP_003807679.1	hypothetical protein	-
F3K97_RS01155	295918..296436	+	519	WP_159140454.1	hypothetical protein	-
F3K97_RS01160	296495..297322	-	828	WP_159140809.1	ATP-binding protein	-
F3K97_RS01165	297652..298281	-	630	WP_055680152.1	response regulator transcription factor	-
F3K97_RS01170	298447..299058	+	612	WP_159140455.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.09 Da
• Isoelectric Point: 8.0955

>T145470 WP_003807675.1 NZ_CP047129:c294007-293708 [Bifidobacterium adolescentis]
MGRLTADFAKAFSRDLKKNAKRRNWNLTELEKVIDLVVENTPETLEELRRRHNMHTLSGNWRGRYECHVANAGDWLVIWS
SNDSVAFFERTGSHDELFR

Nucleotide

• Length: 300 bp

>T145470 NZ_CP062390:1196562-1196750 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9714.91 Da
• Isoelectric Point: 4.5535

>AT145470 WP_034984155.1 NZ_CP047129:c294279-294007 [Bifidobacterium adolescentis]
MSASTLTIRMDDELKRSAADVAEYYGLDLSSVVRAVFKQMVNTGRIPLTFAPEEPNGESLNAAAEADSFMASGKTGRFTN
GHDLLEAAMR

Nucleotide

• Length: 273 bp

>AT145470 NZ_CP062390:1196273-1196533 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2Z6P7