Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 333262..333874 Replicon chromosome
Accession NZ_CP047120
Organism Streptococcus pyogenes strain 1085

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag GQ677_RS01780 Protein ID WP_011018227.1
Coordinates 333262..333597 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag GQ677_RS01785 Protein ID WP_002988079.1
Coordinates 333587..333874 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ677_RS01745 328640..329158 + 519 WP_002982682.1 NYN domain-containing protein -
GQ677_RS01750 329255..330115 + 861 WP_002982687.1 DegV family protein -
GQ677_RS01755 330251..330757 + 507 WP_002988070.1 hypothetical protein -
GQ677_RS01760 330754..330960 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
GQ677_RS01765 331178..331624 + 447 WP_002982710.1 50S ribosomal protein L13 -
GQ677_RS01770 331645..332037 + 393 WP_002982716.1 30S ribosomal protein S9 -
GQ677_RS10300 332157..332594 - 438 WP_111713473.1 site-specific integrase -
GQ677_RS10305 332640..333110 - 471 Protein_283 integrase -
GQ677_RS01780 333262..333597 - 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQ677_RS01785 333587..333874 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
GQ677_RS01790 334534..335307 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
GQ677_RS01795 335754..336182 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
GQ677_RS01800 336217..336732 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
GQ677_RS01805 336780..337709 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
GQ677_RS01810 337713..338696 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T145438 WP_011018227.1 NZ_CP047120:c333597-333262 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T145438 NZ_CP062382:2788948-2789310 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT145438 WP_002988079.1 NZ_CP047120:c333874-333587 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT145438 NZ_CP062382:2788781-2788951 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCTATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References