Detailed information of TA system TA145433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4161349..4162920
• Replicon: chromosome
• Accession: NZ_CP047112
• Organism: Proteus mirabilis strain SCBX1.1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GO498_RS19420
• Protein ID: WP_110706831.1
• Coordinates: 4161349..4162662 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: GO498_RS19425
• Protein ID: WP_004249771.1
• Coordinates: 4162663..4162920 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO498_RS19400	4156519..4157322	+	804	WP_110706833.1	energy transducer TonB	-
GO498_RS19405	4157376..4159337	-	1962	WP_185959285.1	hypothetical protein	-
GO498_RS19410	4159369..4160298	-	930	WP_004246518.1	metallophosphoesterase	-
GO498_RS19415	4160483..4160947	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
GO498_RS19420	4161349..4162662	-	1314	WP_110706831.1	type II toxin-antitoxin system HipA family toxin	Toxin
GO498_RS19425	4162663..4162920	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
GO498_RS19430	4163196..4163825	-	630	WP_001145449.1	hypothetical protein	-
GO498_RS20580	4163968..4164033	+	66	Protein_3773	EAL domain-containing protein	-
GO498_RS19435	4164173..4164937	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
GO498_RS20585	4165055..4165123	-	69	Protein_3775	EAL domain-containing protein	-
GO498_RS19440	4165444..4165944	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
GO498_RS19445	4166072..4166911	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
GO498_RS19450	4166905..4167252	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49659.76 Da
• Isoelectric Point: 6.5023

>T145433 WP_110706831.1 NZ_CP047112:c4162662-4161349 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ASSNQPFDLLVAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T145433 NZ_CP062382:1305081-1305269 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT145433 WP_004249771.1 NZ_CP047112:c4162920-4162663 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT145433 NZ_CP062382:1304792-1305052 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: B4F0T9