Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 10493..11094 | Replicon | chromosome |
| Accession | NZ_CP047112 | ||
| Organism | Proteus mirabilis strain SCBX1.1 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | GO498_RS00045 | Protein ID | WP_049194960.1 |
| Coordinates | 10493..10876 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1Z1SPN9 |
| Locus tag | GO498_RS00050 | Protein ID | WP_004246496.1 |
| Coordinates | 10873..11094 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO498_RS00025 | 6128..7234 | - | 1107 | WP_004249769.1 | aspartate-semialdehyde dehydrogenase | - |
| GO498_RS00030 | 7734..8297 | + | 564 | WP_012368640.1 | methyltransferase | - |
| GO498_RS00035 | 8573..9472 | + | 900 | WP_004246500.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| GO498_RS00040 | 9772..10086 | - | 315 | WP_004246498.1 | helix-turn-helix domain-containing protein | - |
| GO498_RS00045 | 10493..10876 | - | 384 | WP_049194960.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GO498_RS00050 | 10873..11094 | - | 222 | WP_004246496.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GO498_RS00055 | 11375..12238 | - | 864 | WP_004249947.1 | YicC family protein | - |
| GO498_RS00060 | 12365..13081 | + | 717 | WP_004249946.1 | ribonuclease PH | - |
| GO498_RS00065 | 13162..13806 | + | 645 | WP_004246493.1 | orotate phosphoribosyltransferase | - |
| GO498_RS00070 | 14125..14730 | - | 606 | WP_004246491.1 | nucleoid occlusion factor SlmA | - |
| GO498_RS00075 | 14850..15308 | - | 459 | WP_004246490.1 | dUTP diphosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14462.43 Da Isoelectric Point: 6.6451
>T145430 WP_049194960.1 NZ_CP047112:c10876-10493 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN
Download Length: 384 bp
>T145430 NZ_CP062382:19379-19555 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8260.23 Da Isoelectric Point: 5.5667
>AT145430 WP_004246496.1 NZ_CP047112:c11094-10873 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR
Download Length: 222 bp
>AT145430 NZ_CP062382:c19717-19543 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|