Detailed information of TA system TA145430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 10493..11094
• Replicon: chromosome
• Accession: NZ_CP047112
• Organism: Proteus mirabilis strain SCBX1.1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: GO498_RS00045
• Protein ID: WP_049194960.1
• Coordinates: 10493..10876 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: GO498_RS00050
• Protein ID: WP_004246496.1
• Coordinates: 10873..11094 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO498_RS00025	6128..7234	-	1107	WP_004249769.1	aspartate-semialdehyde dehydrogenase	-
GO498_RS00030	7734..8297	+	564	WP_012368640.1	methyltransferase	-
GO498_RS00035	8573..9472	+	900	WP_004246500.1	N-acetylmuramic acid 6-phosphate etherase	-
GO498_RS00040	9772..10086	-	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
GO498_RS00045	10493..10876	-	384	WP_049194960.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
GO498_RS00050	10873..11094	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GO498_RS00055	11375..12238	-	864	WP_004249947.1	YicC family protein	-
GO498_RS00060	12365..13081	+	717	WP_004249946.1	ribonuclease PH	-
GO498_RS00065	13162..13806	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
GO498_RS00070	14125..14730	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
GO498_RS00075	14850..15308	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-115)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14462.43 Da
• Isoelectric Point: 6.6451

>T145430 WP_049194960.1 NZ_CP047112:c10876-10493 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T145430 NZ_CP062382:19379-19555 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT145430 WP_004246496.1 NZ_CP047112:c11094-10873 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT145430 NZ_CP062382:c19717-19543 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9