Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2631214..2631856 Replicon chromosome
Accession NZ_CP047111
Organism Bacillus anthracis strain FDAARGOS_704

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC12_RS13500 Protein ID WP_000635963.1
Coordinates 2631214..2631564 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC12_RS13505 Protein ID WP_000004570.1
Coordinates 2631569..2631856 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC12_RS13485 2628150..2628608 - 459 WP_000344248.1 SprT family protein -
FOC12_RS13490 2628804..2628920 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FOC12_RS13495 2628978..2631146 - 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
FOC12_RS13500 2631214..2631564 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOC12_RS13505 2631569..2631856 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FOC12_RS13510 2632166..2633335 - 1170 WP_000390596.1 alanine racemase -
FOC12_RS13515 2633454..2634404 - 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FOC12_RS13520 2634561..2634920 - 360 WP_000635040.1 holo-ACP synthase -
FOC12_RS13525 2635013..2635585 + 573 WP_000906916.1 rhomboid family intramembrane serine protease -
FOC12_RS13530 2635578..2636540 - 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145429 WP_000635963.1 NZ_CP047111:c2631564-2631214 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145429 NZ_CP062380:2790590-2790916 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAAATTTAATGTGTGATTTAAAGATATTGAAAGAAAAGTTTGAGGATTTAAAGGATAATCATGG
CTCGCATTTTGAAGATTTATATATACATGAGCCAAATCATACCTTAAATAAAGTCGATGTTATTAAAGAAGGGCTTTCAT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145429 WP_000004570.1 NZ_CP047111:c2631856-2631569 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145429 NZ_CP062380:2790378-2790587 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References