Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 4669754..4670729 Replicon chromosome
Accession NZ_CP047107
Organism Bacillus anthracis strain FDAARGOS_705

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC13_RS24240 Protein ID WP_002036394.1
Coordinates 4669992..4670729 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC13_RS24235 Protein ID WP_000588712.1
Coordinates 4669754..4669879 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC13_RS24215 4665508..4665978 + 471 WP_000670597.1 DUF5065 family protein -
FOC13_RS24220 4666542..4668011 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC13_RS27480 4668155..4668331 - 177 WP_000808045.1 hypothetical protein -
FOC13_RS24225 4668670..4668906 + 237 WP_001021689.1 hypothetical protein -
FOC13_RS24230 4669183..4669464 + 282 WP_001041555.1 hypothetical protein -
FOC13_RS27485 4669501..4669677 - 177 WP_000852614.1 hypothetical protein -
FOC13_RS24235 4669754..4669879 - 126 WP_000588712.1 hypothetical protein Antitoxin
FOC13_RS24240 4669992..4670729 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC13_RS24245 4670918..4671655 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC13_RS24250 4671823..4672305 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC13_RS24255 4672412..4674097 + 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
FOC13_RS24260 4674219..4675001 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T145427 WP_002036394.1 NZ_CP047107:c4670729-4669992 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145427 NZ_CP062380:2719075-2719284 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145427 WP_000588712.1 NZ_CP047107:c4669879-4669754 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145427 NZ_CP062380:2718770-2719063 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References