Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1517963..1518605 Replicon chromosome
Accession NZ_CP047107
Organism Bacillus anthracis strain FDAARGOS_705

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC13_RS07775 Protein ID WP_000635963.1
Coordinates 1517963..1518313 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC13_RS07780 Protein ID WP_000004570.1
Coordinates 1518318..1518605 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC13_RS07760 1514899..1515357 - 459 WP_000344248.1 SprT family protein -
FOC13_RS07765 1515553..1515669 + 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FOC13_RS07770 1515727..1517895 - 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
FOC13_RS07775 1517963..1518313 - 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOC13_RS07780 1518318..1518605 - 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FOC13_RS07785 1518915..1520084 - 1170 WP_000390596.1 alanine racemase -
FOC13_RS07790 1520203..1521153 - 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FOC13_RS07795 1521310..1521669 - 360 WP_000635040.1 holo-ACP synthase -
FOC13_RS07800 1521762..1522334 + 573 WP_000906916.1 rhomboid family intramembrane serine protease -
FOC13_RS07805 1522327..1523289 - 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145426 WP_000635963.1 NZ_CP047107:c1518313-1517963 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145426 NZ_CP062380:2661826-2661930 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145426 WP_000004570.1 NZ_CP047107:c1518605-1518318 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145426 NZ_CP062380:c2662089-2661925 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References