Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3227275..3227917 Replicon chromosome
Accession NZ_CP047104
Organism Bacillus anthracis strain FDAARGOS_706

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC14_RS16870 Protein ID WP_000635963.1
Coordinates 3227567..3227917 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC14_RS16865 Protein ID WP_000004570.1
Coordinates 3227275..3227562 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC14_RS16840 3222591..3223553 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
FOC14_RS16845 3223546..3224118 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
FOC14_RS16850 3224211..3224570 + 360 WP_000635040.1 holo-ACP synthase -
FOC14_RS16855 3224727..3225677 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FOC14_RS16860 3225796..3226965 + 1170 WP_000390596.1 alanine racemase -
FOC14_RS16865 3227275..3227562 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FOC14_RS16870 3227567..3227917 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOC14_RS16875 3227985..3230153 + 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
FOC14_RS16880 3230211..3230327 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FOC14_RS16885 3230523..3230981 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145425 WP_000635963.1 NZ_CP047104:3227567-3227917 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145425 NZ_CP062380:2405059-2405325 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145425 WP_000004570.1 NZ_CP047104:3227275-3227562 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145425 NZ_CP062380:2404808-2405059 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References