Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 75149..76124 Replicon chromosome
Accession NZ_CP047104
Organism Bacillus anthracis strain FDAARGOS_706

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC14_RS00410 Protein ID WP_002036394.1
Coordinates 75149..75886 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC14_RS00415 Protein ID WP_000588712.1
Coordinates 75999..76124 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC14_RS00390 70877..71659 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
FOC14_RS00395 71781..73466 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
FOC14_RS00400 73573..74055 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC14_RS00405 74223..74960 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC14_RS00410 75149..75886 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC14_RS00415 75999..76124 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC14_RS27090 76201..76377 + 177 WP_000852614.1 hypothetical protein -
FOC14_RS00420 76414..76695 - 282 WP_001041555.1 hypothetical protein -
FOC14_RS00425 76972..77208 - 237 WP_001021689.1 hypothetical protein -
FOC14_RS27095 77547..77723 + 177 WP_000808045.1 hypothetical protein -
FOC14_RS00430 77867..79336 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC14_RS00435 79900..80370 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T145424 WP_002036394.1 NZ_CP047104:75149-75886 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145424 NZ_CP062380:2379843-2379950 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145424 WP_000588712.1 NZ_CP047104:75999-76124 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145424 NZ_CP062380:c2380027-2379967 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References