145423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2694009..2694984 Replicon chromosome
Accession NZ_CP047099
Organism Bacillus anthracis strain FDAARGOS_700

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC08_RS13745 Protein ID WP_002036394.1
Coordinates 2694009..2694746 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC08_RS13750 Protein ID WP_000588712.1
Coordinates 2694859..2694984 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC08_RS13725 2689737..2690519 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
FOC08_RS13730 2690641..2692326 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
FOC08_RS13735 2692433..2692915 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC08_RS13740 2693083..2693820 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC08_RS13745 2694009..2694746 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC08_RS13750 2694859..2694984 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC08_RS27290 2695061..2695237 + 177 WP_000852614.1 hypothetical protein -
FOC08_RS13755 2695274..2695555 - 282 WP_001041555.1 hypothetical protein -
FOC08_RS13760 2695832..2696068 - 237 WP_001021689.1 hypothetical protein -
FOC08_RS27295 2696407..2696583 + 177 WP_000808045.1 hypothetical protein -
FOC08_RS13765 2696727..2698196 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC08_RS13770 2698760..2699230 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T145423 WP_002036394.1 NZ_CP047099:2694009-2694746 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145423 NZ_CP062380:2348261-2348527 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145423 WP_000588712.1 NZ_CP047099:2694859-2694984 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145423 NZ_CP062380:2348004-2348261 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References