145422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 618692..619334 Replicon chromosome
Accession NZ_CP047099
Organism Bacillus anthracis strain FDAARGOS_700

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC08_RS03135 Protein ID WP_000635963.1
Coordinates 618984..619334 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC08_RS03130 Protein ID WP_000004570.1
Coordinates 618692..618979 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC08_RS03105 614008..614970 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
FOC08_RS03110 614963..615535 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
FOC08_RS03115 615628..615987 + 360 WP_000635040.1 holo-ACP synthase -
FOC08_RS03120 616144..617094 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FOC08_RS03125 617213..618382 + 1170 WP_000390596.1 alanine racemase -
FOC08_RS03130 618692..618979 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FOC08_RS03135 618984..619334 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOC08_RS03140 619402..621570 + 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
FOC08_RS03145 621628..621744 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FOC08_RS03150 621940..622398 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145422 WP_000635963.1 NZ_CP047099:618984-619334 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145422 NZ_CP062380:1265111-1265299 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145422 WP_000004570.1 NZ_CP047099:618692-618979 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145422 NZ_CP062380:1264822-1265082 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References