145420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 74521..75496 Replicon chromosome
Accession NZ_CP047098
Organism Bacillus anthracis strain FDAARGOS_701

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC09_RS00365 Protein ID WP_002036394.1
Coordinates 74759..75496 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC09_RS00360 Protein ID WP_000588712.1
Coordinates 74521..74646 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC09_RS00340 70275..70745 + 471 WP_000670597.1 DUF5065 family protein -
FOC09_RS00345 71309..72778 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC09_RS27075 72922..73098 - 177 WP_000808045.1 hypothetical protein -
FOC09_RS00350 73437..73673 + 237 WP_001021689.1 hypothetical protein -
FOC09_RS00355 73950..74231 + 282 WP_001041555.1 hypothetical protein -
FOC09_RS27080 74268..74444 - 177 WP_000852614.1 hypothetical protein -
FOC09_RS00360 74521..74646 - 126 WP_000588712.1 hypothetical protein Antitoxin
FOC09_RS00365 74759..75496 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC09_RS00370 75685..76422 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC09_RS00375 76590..77072 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC09_RS00380 77179..78864 + 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
FOC09_RS00385 78986..79768 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T145420 WP_002036394.1 NZ_CP047098:c75496-74759 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145420 NZ_CP062380:62794-62970 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145420 WP_000588712.1 NZ_CP047098:c74646-74521 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145420 NZ_CP062380:c63132-62958 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References