145419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4618706..4619348 Replicon chromosome
Accession NZ_CP047097
Organism Bacillus anthracis strain FDAARGOS_698

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC06_RS23935 Protein ID WP_000635963.1
Coordinates 4618998..4619348 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC06_RS23930 Protein ID WP_000004570.1
Coordinates 4618706..4618993 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC06_RS23905 4614022..4614984 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
FOC06_RS23910 4614977..4615549 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
FOC06_RS23915 4615642..4616001 + 360 WP_000635040.1 holo-ACP synthase -
FOC06_RS23920 4616158..4617108 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FOC06_RS23925 4617227..4618396 + 1170 WP_000390596.1 alanine racemase -
FOC06_RS23930 4618706..4618993 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FOC06_RS23935 4618998..4619348 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FOC06_RS23940 4619416..4621584 + 2169 WP_000426223.1 RNA-binding transcriptional accessory protein -
FOC06_RS23945 4621642..4621758 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FOC06_RS23950 4621954..4622412 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145419 WP_000635963.1 NZ_CP047097:4618998-4619348 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145419 NZ_CP062380:19380-19556 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145419 WP_000004570.1 NZ_CP047097:4618706-4618993 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145419 NZ_CP062380:c19718-19544 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References