Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1466590..1467565 Replicon chromosome
Accession NZ_CP047097
Organism Bacillus anthracis strain FDAARGOS_698

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FOC06_RS07475 Protein ID WP_002036394.1
Coordinates 1466590..1467327 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FOC06_RS07480 Protein ID WP_000588712.1
Coordinates 1467440..1467565 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC06_RS07455 1462318..1463100 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
FOC06_RS07460 1463222..1464907 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
FOC06_RS07465 1465014..1465496 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FOC06_RS07470 1465664..1466401 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FOC06_RS07475 1466590..1467327 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FOC06_RS07480 1467440..1467565 + 126 WP_000588712.1 hypothetical protein Antitoxin
FOC06_RS27190 1467642..1467818 + 177 WP_000852614.1 hypothetical protein -
FOC06_RS07485 1467855..1468136 - 282 WP_001041555.1 hypothetical protein -
FOC06_RS07490 1468413..1468649 - 237 WP_001021689.1 hypothetical protein -
FOC06_RS27195 1468988..1469164 + 177 WP_000808045.1 hypothetical protein -
FOC06_RS07495 1469308..1470777 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FOC06_RS07500 1471341..1471811 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T145418 WP_002036394.1 NZ_CP047097:1466590-1467327 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145418 NZ_CP062378:c2158920-2158654 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145418 WP_000588712.1 NZ_CP047097:1467440-1467565 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145418 NZ_CP062378:c2159177-2158920 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References