145417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4767403..4768045 Replicon chromosome
Accession NZ_CP047085
Organism Bacillus paranthracis strain BC307

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag GQZ26_RS24610 Protein ID WP_000635963.1
Coordinates 4767695..4768045 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag GQZ26_RS24605 Protein ID WP_000004570.1
Coordinates 4767403..4767690 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQZ26_RS24580 4762729..4763691 + 963 WP_000961151.1 UV DNA damage repair endonuclease UvsE -
GQZ26_RS24585 4763684..4764256 - 573 WP_000906919.1 rhomboid family intramembrane serine protease -
GQZ26_RS24590 4764349..4764708 + 360 WP_000635037.1 holo-ACP synthase -
GQZ26_RS24595 4764865..4765815 + 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
GQZ26_RS24600 4765934..4767103 + 1170 WP_000390601.1 alanine racemase -
GQZ26_RS24605 4767403..4767690 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
GQZ26_RS24610 4767695..4768045 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GQZ26_RS24615 4768113..4770281 + 2169 WP_000450602.1 RNA-binding transcriptional accessory protein -
GQZ26_RS24620 4770339..4770455 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
GQZ26_RS24625 4770651..4771109 + 459 WP_000344246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T145417 WP_000635963.1 NZ_CP047085:4767695-4768045 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T145417 NZ_CP062378:c2127636-2127529 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT145417 WP_000004570.1 NZ_CP047085:4767403-4767690 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT145417 NZ_CP062378:2127452-2127512 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References