Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1667942..1668917 Replicon chromosome
Accession NZ_CP047085
Organism Bacillus paranthracis strain BC307

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag GQZ26_RS08545 Protein ID WP_002027714.1
Coordinates 1667942..1668679 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag GQZ26_RS08550 Protein ID WP_000588712.1
Coordinates 1668792..1668917 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQZ26_RS08520 1663017..1663727 + 711 WP_000787481.1 class I SAM-dependent methyltransferase -
GQZ26_RS08525 1663847..1664254 + 408 WP_000072484.1 VOC family protein -
GQZ26_RS28885 1664360..1664452 + 93 Protein_1710 methyltransferase -
GQZ26_RS08530 1664574..1666259 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
GQZ26_RS08535 1666366..1666848 + 483 WP_000191904.1 MarR family winged helix-turn-helix transcriptional regulator -
GQZ26_RS08540 1667016..1667753 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
GQZ26_RS08545 1667942..1668679 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
GQZ26_RS08550 1668792..1668917 + 126 WP_000588712.1 hypothetical protein Antitoxin
GQZ26_RS08555 1669312..1670781 + 1470 WP_000287521.1 beta-Ala-His dipeptidase -
GQZ26_RS08560 1670858..1671229 - 372 WP_000670600.1 DUF5065 family protein -
GQZ26_RS08565 1671372..1671965 + 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
GQZ26_RS08570 1672187..1672720 + 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
GQZ26_RS08575 1672710..1673537 + 828 WP_001060779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T145416 WP_002027714.1 NZ_CP047085:1667942-1668679 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T145416 NZ_CP062378:c2102223-2101957 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT145416 WP_000588712.1 NZ_CP047085:1668792-1668917 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT145416 NZ_CP062378:c2102474-2102223 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References