Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1790468..1791090 Replicon chromosome
Accession NZ_CP047073
Organism Pseudomonas syringae pv. tomato strain delta X

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag GRB21_RS08805 Protein ID WP_011103638.1
Coordinates 1790468..1790650 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag GRB21_RS08810 Protein ID WP_005767619.1
Coordinates 1790686..1791090 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRB21_RS08795 1786659..1788407 - 1749 WP_005767614.1 N-acetylglutaminylglutamine synthetase -
GRB21_RS08800 1788411..1790183 - 1773 WP_011103637.1 N-acetylglutaminylglutamine amidotransferase -
GRB21_RS08805 1790468..1790650 + 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
GRB21_RS08810 1790686..1791090 + 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GRB21_RS08815 1791106..1792185 - 1080 WP_046463929.1 iron ABC transporter permease -
GRB21_RS08820 1792175..1794652 - 2478 WP_011103640.1 ABC transporter permease -
GRB21_RS08825 1794652..1795320 - 669 WP_011103641.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T145413 WP_011103638.1 NZ_CP047073:1790468-1790650 [Pseudomonas syringae pv. tomato]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

>T145413 NZ_CP062378:c1764043-1763681 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT145413 WP_005767619.1 NZ_CP047073:1790686-1791090 [Pseudomonas syringae pv. tomato]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT145413 NZ_CP062378:c1764210-1764040 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References