145389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 18376..18841 Replicon plasmid unnamed
Accession NZ_CP047058
Organism Escherichia coli NC101

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag GQ584_RS24200 Protein ID WP_001230707.1
Coordinates 18376..18627 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag GQ584_RS24205 Protein ID WP_000801440.1
Coordinates 18614..18841 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ584_RS24175 (GQ584_23910) 15681..15932 + 252 WP_000121743.1 plasmid stabilization protein -
GQ584_RS24180 (GQ584_23915) 15922..16203 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQ584_RS24185 (GQ584_23920) 16227..16577 + 351 WP_000312755.1 hypothetical protein -
GQ584_RS24190 (GQ584_23925) 17217..17732 + 516 WP_001025397.1 J domain-containing protein -
GQ584_RS24195 (GQ584_23930) 17837..18379 + 543 WP_001083906.1 hypothetical protein -
GQ584_RS24200 (GQ584_23935) 18376..18627 + 252 WP_001230707.1 hypothetical protein Toxin
GQ584_RS24205 (GQ584_23940) 18614..18841 + 228 WP_000801440.1 hypothetical protein Antitoxin
GQ584_RS24210 (GQ584_23945) 19295..19594 + 300 WP_000650308.1 hypothetical protein -
GQ584_RS24215 (GQ584_23950) 19686..20036 + 351 WP_000854261.1 hypothetical protein -
GQ584_RS24220 (GQ584_23955) 20342..20590 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
GQ584_RS24225 (GQ584_23960) 20587..20934 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
GQ584_RS24230 (GQ584_23965) 21298..21801 + 504 WP_000781818.1 DNA distortion polypeptide 1 -
GQ584_RS24235 (GQ584_23970) 21805..23034 + 1230 WP_024199200.1 DNA relaxase/nickase TaxC -
GQ584_RS24240 (GQ584_23975) 23111..23377 + 267 WP_000160396.1 hypothetical protein -
GQ584_RS24245 (GQ584_23980) 23382..23615 + 234 WP_000121162.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45203 45203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T145389 WP_001230707.1 NZ_CP047058:18376-18627 [Escherichia coli NC101]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T145389 NZ_CP062370:2582569-2582673 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT145389 WP_000801440.1 NZ_CP047058:18614-18841 [Escherichia coli NC101]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT145389 NZ_CP062370:c2582831-2582668 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References