Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1302221..1303016 Replicon chromosome
Accession NZ_CP047057
Organism Escherichia coli NC101

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag GQ584_RS06250 Protein ID WP_001094434.1
Coordinates 1302642..1303016 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag GQ584_RS06245 Protein ID WP_001285482.1
Coordinates 1302221..1302595 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ584_RS06220 (1299101) 1299101..1299922 + 822 WP_001234582.1 DUF932 domain-containing protein -
GQ584_RS06225 (1300259) 1300259..1300732 + 474 WP_001313575.1 antirestriction protein -
GQ584_RS06230 (1300748) 1300748..1301224 + 477 WP_001313574.1 RadC family protein -
GQ584_RS06235 (1301287) 1301287..1301508 + 222 WP_000692315.1 DUF987 domain-containing protein -
GQ584_RS06240 (1301527) 1301527..1302171 + 645 WP_000086762.1 hypothetical protein -
GQ584_RS06245 (1302221) 1302221..1302595 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GQ584_RS06250 (1302642) 1302642..1303016 + 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
GQ584_RS06255 (1303013) 1303013..1303504 + 492 WP_000976859.1 DUF5983 family protein -
GQ584_RS06260 (1303516) 1303516..1303713 + 198 WP_000839257.1 DUF957 domain-containing protein -
GQ584_RS06265 (1303806) 1303806..1304648 + 843 WP_001280460.1 DUF4942 domain-containing protein -
GQ584_RS06275 (1305119) 1305119..1306057 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
GQ584_RS06280 (1306112) 1306112..1306849 + 738 WP_000283656.1 zinc-binding phosphatase -
GQ584_RS06285 (1306873) 1306873..1307427 + 555 WP_001001913.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T145370 WP_001094434.1 NZ_CP047057:1302642-1303016 [Escherichia coli NC101]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T145370 NZ_CP062366:2825113-2825322 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT145370 WP_001285482.1 NZ_CP047057:1302221-1302595 [Escherichia coli NC101]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT145370 NZ_CP062366:2824808-2825101 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References