Detailed information of TA system TA145363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2911716..2912209
• Replicon: chromosome
• Accession: NZ_CP047056
• Organism: Succinivibrio dextrinosolvens strain Z6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A662Z824
• Locus tag: SDZ_RS12890
• Protein ID: WP_074838001.1
• Coordinates: 2911940..2912209 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A662Z5Y0
• Locus tag: SDZ_RS12885
• Protein ID: WP_074838003.1
• Coordinates: 2911716..2911937 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDZ_RS12860	2908470..2908910	+	441	WP_074838016.1	RusA family crossover junction endodeoxyribonuclease	-
SDZ_RS12865	2908979..2909368	+	390	WP_074838014.1	DUF2513 domain-containing protein	-
SDZ_RS12870	2909376..2909828	+	453	WP_074838012.1	hypothetical protein	-
SDZ_RS12875	2910155..2910829	+	675	WP_074838008.1	hypothetical protein	-
SDZ_RS12880	2911085..2911654	+	570	WP_074838006.1	hypothetical protein	-
SDZ_RS12885	2911716..2911937	+	222	WP_074838003.1	toxin-antitoxin system protein	Antitoxin
SDZ_RS12890	2911940..2912209	+	270	WP_074838001.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SDZ_RS12895	2912359..2912691	+	333	WP_143075355.1	hypothetical protein	-
SDZ_RS12900	2912861..2913304	+	444	WP_074837997.1	lysozyme	-
SDZ_RS12905	2913710..2913901	+	192	WP_074837995.1	hypothetical protein	-
SDZ_RS12910	2913877..2914371	+	495	WP_074837993.1	hypothetical protein	-
SDZ_RS12915	2914399..2915139	-	741	WP_074837991.1	hypothetical protein	-
SDZ_RS12920	2915217..2917064	+	1848	WP_074837988.1	phage terminase large subunit family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2894498..2958073	63575

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10666.48 Da
• Isoelectric Point: 9.9525

>T145363 WP_074838001.1 NZ_CP047056:2911940-2912209 [Succinivibrio dextrinosolvens]
MKYQVVYSKRSIKEFKKLDRSIAIFIKSWIEDNLVDCENPRIHGKALKGNLASFWRYRIGDYRLICDIRDEECVIIAVTV
GRRREIYRP

Nucleotide

• Length: 270 bp

>T145363 NZ_CP062366:164892-165044 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8577.64 Da
• Isoelectric Point: 4.4118

>AT145363 WP_074838003.1 NZ_CP047056:2911716-2911937 [Succinivibrio dextrinosolvens]
MAFSIRLNPQEEKLARGYANLNGISLGEAFKRALFEKIEDEYDIRMAEEAYKEFLKDPVTYSHEEAWAEIFKD

Nucleotide

• Length: 222 bp

>AT145363 NZ_CP062366:164268-164867 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A662Z824

Antitoxin

• AlphaFold DB: A0A662Z5Y0