Detailed information of TA system TA145361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 681115..681608
• Replicon: chromosome
• Accession: NZ_CP047056
• Organism: Succinivibrio dextrinosolvens strain Z6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SDZ_RS02905
• Protein ID: WP_164954213.1
• Coordinates: 681339..681608 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SDZ_RS02900
• Protein ID: WP_164954212.1
• Coordinates: 681115..681336 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDZ_RS02880	676253..678031	-	1779	WP_164954209.1	AAA family ATPase	-
SDZ_RS02885	678463..680244	-	1782	WP_164954210.1	AAA family ATPase	-
SDZ_RS02890	680411..680788	+	378	WP_164954211.1	restriction endonuclease subunit S	-
SDZ_RS02895	680851..680973	-	123	WP_164954529.1	helix-turn-helix transcriptional regulator	-
SDZ_RS02900	681115..681336	+	222	WP_164954212.1	toxin-antitoxin system protein	Antitoxin
SDZ_RS02905	681339..681608	+	270	WP_164954213.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SDZ_RS02910	682172..682348	-	177	WP_164954214.1	hypothetical protein	-
SDZ_RS02915	682774..684270	+	1497	WP_164954215.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
SDZ_RS02920	684343..686304	+	1962	WP_164954216.1	filamentous hemagglutinin N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10448.32 Da
• Isoelectric Point: 10.4105

>T145361 WP_164954213.1 NZ_CP047056:681339-681608 [Succinivibrio dextrinosolvens]
MKYTVVYSKQSIKELKKLNRSIAVFIKSWIEKNLVGCENPRIHGKAQKGNLATLWRYRIGDYRLVCDIRDNECIILAVAI
GHRREVYRP

Nucleotide

• Length: 270 bp

>T145361 NZ_CP062364:c2373867-2373601 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8578.67 Da
• Isoelectric Point: 4.4118

>AT145361 WP_164954212.1 NZ_CP047056:681115-681336 [Succinivibrio dextrinosolvens]
MAFSIRLNPQEEKLARAYATLNGISLGEAFKRALFEKIEDEYDIRMAEEAYKEFLKDPVTYSHEEAWAEIFKD

Nucleotide

• Length: 222 bp

>AT145361 NZ_CP062364:c2374118-2373867 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA