Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 519529..520082 Replicon chromosome
Accession NZ_CP047056
Organism Succinivibrio dextrinosolvens strain Z6

Toxin (Protein)


Gene name relE Uniprot ID A0A662Z9X8
Locus tag SDZ_RS02250 Protein ID WP_074839745.1
Coordinates 519529..519813 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A662Z7U9
Locus tag SDZ_RS02255 Protein ID WP_074839748.1
Coordinates 519810..520082 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDZ_RS02235 515972..517213 + 1242 WP_074841473.1 hypothetical protein -
SDZ_RS02240 517839..519053 - 1215 WP_206735617.1 transposase -
SDZ_RS02245 519219..519515 + 297 WP_074839743.1 hypothetical protein -
SDZ_RS02250 519529..519813 - 285 WP_074839745.1 type II toxin-antitoxin system YafQ family toxin Toxin
SDZ_RS02255 519810..520082 - 273 WP_074839748.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SDZ_RS02260 520875..521096 + 222 WP_143075375.1 hypothetical protein -
SDZ_RS02265 521166..522146 + 981 WP_074839752.1 DUF2628 domain-containing protein -
SDZ_RS02270 522265..522627 - 363 WP_074839758.1 hypothetical protein -
SDZ_RS02275 522763..524139 - 1377 WP_074839760.1 exopolysaccharide Pel transporter PelG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-72)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11175.90 Da        Isoelectric Point: 7.8839

>T145360 WP_074839745.1 NZ_CP047056:c519813-519529 [Succinivibrio dextrinosolvens]
MTKQVIWTKQFKKDYKLAMKRNLNIELLDDIIRKIANDIPLSETNRDHSLNGNWKCFRECHIQPDWLLIYQISDDLLVLS
LTRTGTHSDLFSKE

Download         Length: 285 bp

>T145360 NZ_CP062364:c2037149-2036940 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCATATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10223.88 Da        Isoelectric Point: 5.8580

>AT145360 WP_074839748.1 NZ_CP047056:c520082-519810 [Succinivibrio dextrinosolvens]
MANTINFTCRIESDVKQKGEILFKELGMSLSTAINVFLKESIRKGGFPFDVCLQRPNMDTLSAMLESDKLLHDPDAKKYD
LEDALKELKK

Download         Length: 273 bp

>AT145360 NZ_CP062364:c2037454-2037161 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A662Z9X8

Antitoxin

Source ID Structure
AlphaFold DB A0A662Z7U9

References