145359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2294668..2295278 Replicon chromosome
Accession NZ_CP047045
Organism Terricaulis silvestris strain 0127_4

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DSM104635_RS11750 Protein ID WP_158766381.1
Coordinates 2294970..2295278 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DSM104635_RS11745 Protein ID WP_158766380.1
Coordinates 2294668..2294973 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM104635_RS11715 2290229..2290633 - 405 WP_158766374.1 OmpA family protein -
DSM104635_RS11720 2290845..2291447 + 603 WP_158766375.1 DNA-3-methyladenine glycosylase I -
DSM104635_RS11725 2291486..2291869 + 384 WP_158766376.1 VOC family protein -
DSM104635_RS11730 2291870..2292580 - 711 WP_158766377.1 RlmE family RNA methyltransferase -
DSM104635_RS11735 2292577..2293620 - 1044 WP_158766378.1 Ppx/GppA family phosphatase -
DSM104635_RS11740 2293860..2294183 + 324 WP_158766379.1 heat shock protein HspQ -
DSM104635_RS11745 2294668..2294973 - 306 WP_158766380.1 putative addiction module antidote protein Antitoxin
DSM104635_RS11750 2294970..2295278 - 309 WP_158766381.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSM104635_RS11755 2295333..2296673 - 1341 WP_158766382.1 N-succinylarginine dihydrolase -
DSM104635_RS11760 2296670..2298118 - 1449 WP_158766383.1 succinylglutamate-semialdehyde dehydrogenase -
DSM104635_RS11765 2298108..2299121 - 1014 WP_158768080.1 arginine N-succinyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-85)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11157.95 Da        Isoelectric Point: 10.4275

>T145359 WP_158766381.1 NZ_CP047045:c2295278-2294970 [Terricaulis silvestris]
VPKVIETEAFATWLSALKDSVAKTRIVARIKRLAAGSPGDVKPVGDGVSELRFRFGPGYRVYFAKRGEELIIILGGGDKD
TQARDIKAALKLWGEVKKEDSK

Download         Length: 309 bp

>T145359 NZ_CP062364:c2017562-2017200 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10834.17 Da        Isoelectric Point: 4.3055

>AT145359 WP_158766380.1 NZ_CP047045:c2294973-2294668 [Terricaulis silvestris]
MSVKTRPFDAANYLDTPEDVANYLDAMFEDALEHDDTSLIAAALGDVARSKGMAVIADQTGLSRESLYRTLSEAGNPTLS
TLNSVLNAMGLRLSVKALERA

Download         Length: 306 bp

>AT145359 NZ_CP062364:c2017729-2017559 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References