Detailed information of TA system TA145358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1410271..1410818
• Replicon: chromosome
• Accession: NZ_CP047045
• Organism: Terricaulis silvestris strain 0127_4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DSM104635_RS07055
• Protein ID: WP_158765531.1
• Coordinates: 1410519..1410818 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DSM104635_RS07050
• Protein ID: WP_158765530.1
• Coordinates: 1410271..1410519 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSM104635_RS07015	1405612..1405971	+	360	WP_158765523.1	hypothetical protein	-
DSM104635_RS07020	1406003..1407289	+	1287	WP_158765524.1	DUF3667 domain-containing protein	-
DSM104635_RS07025	1407286..1407681	+	396	WP_158765525.1	hypothetical protein	-
DSM104635_RS07030	1407645..1408625	+	981	WP_158765526.1	sterol desaturase family protein	-
DSM104635_RS07035	1408626..1409273	+	648	WP_158765527.1	FMN-binding negative transcriptional regulator	-
DSM104635_RS07040	1409263..1409781	+	519	WP_158765528.1	hypothetical protein	-
DSM104635_RS07045	1409778..1410230	+	453	WP_158765529.1	DUF1489 domain-containing protein	-
DSM104635_RS07050	1410271..1410519	+	249	WP_158765530.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
DSM104635_RS07055	1410519..1410818	+	300	WP_158765531.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DSM104635_RS07060	1410804..1412003	-	1200	WP_158768031.1	class V aminotransferase	-
DSM104635_RS07065	1411979..1412767	-	789	WP_158765532.1	tryptophan 2,3-dioxygenase	-
DSM104635_RS19780	1412935..1414020	+	1086	WP_187448174.1	hypothetical protein	-
DSM104635_RS07075	1414123..1414800	+	678	WP_158765533.1	nitroreductase	-
DSM104635_RS07080	1414844..1415122	-	279	WP_158765534.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11833.41 Da
• Isoelectric Point: 10.1857

>T145358 WP_158765531.1 NZ_CP047045:1410519-1410818 [Terricaulis silvestris]
MARYTIRERAQADLIDIWRFTSRRWDLNQADSYYREIISALEAVAQEPSLGRPCDEIRHGYRRHNVGSHVVFYRLESGIP
DVIRILHGRRDFRRHLPKS

Nucleotide

• Length: 300 bp

>T145358 NZ_CP062364:c1863005-1862853 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8893.98 Da
• Isoelectric Point: 4.4989

>AT145358 WP_158765530.1 NZ_CP047045:1410271-1410519 [Terricaulis silvestris]
MTKQTTIELPEHQASFAEERVAEGAYGSVSEVVQAGLRLLEEQEAKLAQLRAALLEGEQSTIVEGFDAEALLSKLHVGRA
SR

Nucleotide

• Length: 249 bp

>AT145358 NZ_CP062364:c1863629-1863030 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGTTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA