Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 616100..617715 Replicon chromosome
Accession NZ_CP047024
Organism Paraglaciecola sp. L1A13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GQR89_RS02560 Protein ID WP_158768611.1
Coordinates 616100..617422 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GQR89_RS02565 Protein ID WP_158768612.1
Coordinates 617422..617715 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQR89_RS02545 612522..613259 - 738 WP_158768609.1 ABC transporter ATP-binding protein -
GQR89_RS02550 613735..614712 + 978 WP_158768610.1 DUF1852 domain-containing protein -
GQR89_RS02555 614786..615820 + 1035 WP_158772109.1 methionine synthase -
GQR89_RS02560 616100..617422 - 1323 WP_158768611.1 type II toxin-antitoxin system HipA family toxin Toxin
GQR89_RS02565 617422..617715 - 294 WP_158768612.1 helix-turn-helix domain-containing protein Antitoxin
GQR89_RS02570 617971..619620 - 1650 WP_158768613.1 chaperonin GroEL -
GQR89_RS02575 619655..619945 - 291 WP_158768614.1 co-chaperone GroES -
GQR89_RS02580 620328..620999 + 672 WP_158768615.1 DsbA family oxidoreductase -
GQR89_RS02585 621217..622383 - 1167 WP_158768616.1 iron-containing alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50059.17 Da        Isoelectric Point: 9.3466

>T145356 WP_158768611.1 NZ_CP047024:c617422-616100 [Paraglaciecola sp. L1A13]
MAILDVYMNGYLIGEFTKSANGSHMFKYGLKWLETPGSRPISLSMPLQRKQYMGTDVYNFFDNLLPDTIEIRNKIVARHD
AQSTQAFDLLEKIGQDSVGALQLIPHKQPAPDVKKIESKPLSNKALEKILKGYESDMPLGMLKEEEDFRISLAGAQEKTA
LLNLQGQWHLPLKNTPTTHIMKLPIGEIKTHSHIIDMTDSVENEYLCMMIVREFGLDVPQCSIIKVGDIRALAVERFDRR
RSSDGEWIMRLPQEDFCQTLNVPSAKKYESHGGPSIKKIMDYLLGSMNSQKDRLDFMKSQLLFWLLAATDGHAKNFSLHI
HAGGAYFLTPFYDILSVYPVMGGRGLNIRDAKLAMGLKATKGKKYLINDIFPRHFLDTAKDVGFDIEMMVNIMTQVVNDL
DSVITRVERQLKRDFPVHIKNAIFKGMKNRAKRLADYKTQ

Download         Length: 1323 bp

>T145356 NZ_CP062364:c818933-818745 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10963.34 Da        Isoelectric Point: 9.6856

>AT145356 WP_158768612.1 NZ_CP047024:c617715-617422 [Paraglaciecola sp. L1A13]
MKVTNSKQLSAYIKDIRLNQKQSQTDTAKKVGIRQDTISSFELNPDSTKLNTLFKILSALNLELEVKVRNSTLSEQQQGN
SCAASINTSDSKWKEEW

Download         Length: 294 bp

>AT145356 NZ_CP062364:c819222-818962 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References