Detailed information of TA system TA145355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2787904..2789493
• Replicon: chromosome
• Accession: NZ_CP047023
• Organism: Paraglaciecola sp. L3A3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GQR87_RS11630
• Protein ID: WP_158969497.1
• Coordinates: 2788171..2789493 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GQR87_RS11625
• Protein ID: WP_158969495.1
• Coordinates: 2787904..2788170 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQR87_RS11615	2785019..2786374	+	1356	WP_158969491.1	DUF1552 domain-containing protein	-
GQR87_RS11620	2786382..2787497	+	1116	WP_158969493.1	ankyrin repeat domain-containing protein	-
GQR87_RS11625	2787904..2788170	+	267	WP_158969495.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GQR87_RS11630	2788171..2789493	+	1323	WP_158969497.1	type II toxin-antitoxin system HipA family toxin	Toxin
GQR87_RS11635	2789872..2790114	+	243	WP_199271607.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GQR87_RS11640	2790111..2790386	+	276	WP_158969498.1	helix-turn-helix transcriptional regulator	-
GQR87_RS11645	2790727..2790954	+	228	WP_158972991.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GQR87_RS11650	2790951..2791226	+	276	WP_158969500.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (154-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-63)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48901.76 Da
• Isoelectric Point: 8.8873

>T145355 WP_158969497.1 NZ_CP047023:2788171-2789493 [Paraglaciecola sp. L3A3]
MTKLSIYMNDEYVGELVKSANGAHQLHYATDWLTHPKARPLSLSLPLQKGKITSAQVYNYFDNLLPDSQLVRERIVKRFT
AASAQPFDLLSEIGKDSIGAITLLTESIAQTSLPLNNRTLLYAKLADEQLITLLQGHKADAPLGMIQEQTDFRISVAGAQ
EKTALLKINDSWCVPKGLTPTSHIIKLPIGQIKGPSATLDLSDSVENEWLCIELARELGFSVPNIEIIKVADVKALAVER
FDRRWSADKNWLIRLPQEDMCQAHGVPPAIKYESDGGPGIAEIMKLLMGSKNALLDRDSFMRFQVFQWLIGATDGHAKNF
SIFLDAGGAYRMTPFYDILSAYPILGGTGLNIRELSLAMGLTATKGKKRKLEMIFPRHFISTAKAVGFDTSRMKDIMDEF
AVSLPLAIEKLQQRIPPNIPVRIQDAIFSNALKQAQRLKI

Nucleotide

• Length: 1323 bp

>T145355 NZ_CP062362:2658862-2659224 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10131.46 Da
• Isoelectric Point: 6.4526

>AT145355 WP_158969495.1 NZ_CP047023:2787904-2788170 [Paraglaciecola sp. L3A3]
MIYGPQQLANHLKLIRTNNNWSQAEIAKRVGVKQATISNFENEPDRCQLQTLFKIMQALHVSMLIQTQDNGSQYPLSDAE
DKKVTEDW

Nucleotide

• Length: 267 bp

>AT145355 NZ_CP062362:2658695-2658865 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA