Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2139149..2139663 Replicon chromosome
Accession NZ_CP047021
Organism Staphylococcus aureus strain M2024

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GQX63_RS10595 Protein ID WP_000581792.1
Coordinates 2139149..2139358 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GQX63_RS10600 Protein ID WP_000138932.1
Coordinates 2139370..2139663 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX63_RS10575 2134657..2136015 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
GQX63_RS10580 2136030..2137100 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
GQX63_RS10585 2137418..2138620 + 1203 WP_001109939.1 rod shape-determining protein RodA -
GQX63_RS10590 2138884..2139021 - 138 WP_000828354.1 hypothetical protein -
GQX63_RS10595 2139149..2139358 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GQX63_RS10600 2139370..2139663 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GQX63_RS10605 2139829..2141313 + 1485 WP_086095158.1 cardiolipin synthase -
GQX63_RS10610 2141341..2141988 + 648 WP_001187630.1 HD domain-containing protein -
GQX63_RS10615 2142454..2143326 - 873 WP_000725802.1 membrane protein insertase YidC -
GQX63_RS10620 2143412..2144053 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T145345 WP_000581792.1 NZ_CP047021:c2139358-2139149 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T145345 NZ_CP062362:18832-19008 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT145345 WP_000138932.1 NZ_CP047021:c2139663-2139370 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT145345 NZ_CP062362:c19170-18996 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References