Detailed information of TA system TA145339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1921784..1922560
• Replicon: chromosome
• Accession: NZ_CP047021
• Organism: Staphylococcus aureus strain M2024

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: GQX63_RS09265
• Protein ID: WP_000031108.1
• Coordinates: 1921784..1921936 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: GQX63_RS09270
• Protein ID: WP_086203189.1
• Coordinates: 1921961..1922560 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX63_RS09250	1917921..1918742	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
GQX63_RS09255	1919205..1920590	-	1386	WP_000116229.1	class II fumarate hydratase	-
GQX63_RS09260	1920786..1921181	-	396	WP_000901023.1	hypothetical protein	-
GQX63_RS09265	1921784..1921936	-	153	WP_000031108.1	hypothetical protein	Toxin
GQX63_RS09270	1921961..1922560	-	600	WP_086203189.1	glucosamine-6-phosphate isomerase	Antitoxin
GQX63_RS09275	1922719..1923189	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
GQX63_RS09280	1923194..1924321	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
GQX63_RS09285	1924472..1925194	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
GQX63_RS09290	1925187..1926644	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T145339 WP_000031108.1 NZ_CP047021:c1921936-1921784 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T145339 NZ_CP062360:c1981215-1981039 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22317.44 Da
• Isoelectric Point: 5.1445

>AT145339 WP_086203189.1 NZ_CP047021:c1922560-1921961 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEAADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT145339 NZ_CP062360:1980908-1981049 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• AlphaFold DB: X5E2E6