Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837427..837904 Replicon chromosome
Accession NZ_CP047021
Organism Staphylococcus aureus strain M2024

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GQX63_RS03935 Protein ID WP_000052076.1
Coordinates 837427..837615 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GQX63_RS03940 Protein ID WP_001059690.1
Coordinates 837644..837904 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX63_RS03905 833468..833938 + 471 WP_000824472.1 hypothetical protein -
GQX63_RS03910 834279..834965 + 687 WP_001566557.1 thermonuclease family protein -
GQX63_RS03915 835322..835522 + 201 WP_001059082.1 cold-shock protein -
GQX63_RS03920 836018..836236 - 219 WP_000005886.1 hypothetical protein -
GQX63_RS03925 836298..836582 - 285 WP_001004401.1 hypothetical protein -
GQX63_RS03930 836670..837239 - 570 WP_045178121.1 orthopoxovirus protein, PF05708 family -
GQX63_RS03935 837427..837615 - 189 WP_000052076.1 hypothetical protein Toxin
GQX63_RS03940 837644..837904 - 261 WP_001059690.1 hypothetical protein Antitoxin
GQX63_RS03945 838245..838448 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GQX63_RS03950 838445..838681 - 237 WP_000368687.1 hypothetical protein -
GQX63_RS03955 838906..839487 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
GQX63_RS03960 839560..840177 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
GQX63_RS03965 840332..840826 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
GQX63_RS03970 841225..841647 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
GQX63_RS03975 841795..842511 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T145335 WP_000052076.1 NZ_CP047021:c837615-837427 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T145335 NZ_CP062360:401293-401598 [Staphylococcus aureus]
ATGAATTTGGAAATTAAAGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGCTATATCCACATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATATCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT145335 WP_001059690.1 NZ_CP047021:c837904-837644 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT145335 NZ_CP062360:401081-401290 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References