Detailed information of TA system TA145334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3859991..3860558
• Replicon: chromosome
• Accession: NZ_CP047019
• Organism: Streptomyces sp. ST1015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A7X85_RS17075
• Protein ID: WP_112474242.1
• Coordinates: 3859991..3860272 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A7X85_RS17080
• Protein ID: WP_240001224.1
• Coordinates: 3860277..3860558 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7X85_RS17045 (A7X85_17120)	3855360..3855797	-	438	WP_109362240.1	ribosome silencing factor	-
A7X85_RS17050 (A7X85_17125)	3855873..3857558	-	1686	WP_112474243.1	LCP family protein	-
A7X85_RS17055 (A7X85_17130)	3857584..3858210	-	627	WP_055722179.1	nicotinate-nucleotide adenylyltransferase	-
A7X85_RS17060 (A7X85_17135)	3858255..3858419	-	165	WP_165854480.1	hypothetical protein	-
A7X85_RS17065 (A7X85_17140)	3858542..3858685	-	144	WP_165854481.1	hypothetical protein	-
A7X85_RS17070 (A7X85_17145)	3858840..3859937	+	1098	WP_055722178.1	M48 family metallopeptidase	-
A7X85_RS17075 (A7X85_17150)	3859991..3860272	-	282	WP_112474242.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7X85_RS17080 (A7X85_17155)	3860277..3860558	-	282	WP_240001224.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A7X85_RS17085 (A7X85_17160)	3860597..3861667	-	1071	WP_112474240.1	hypothetical protein	-
A7X85_RS17090 (A7X85_17165)	3861745..3862305	-	561	WP_193555431.1	hypothetical protein	-
A7X85_RS17095 (A7X85_17170)	3862396..3863679	-	1284	WP_055721472.1	glutamate-5-semialdehyde dehydrogenase	-
A7X85_RS17100 (A7X85_17175)	3863740..3864165	-	426	WP_055721473.1	hypothetical protein	-
A7X85_RS17105 (A7X85_17180)	3864347..3865477	-	1131	WP_112474238.1	glutamate 5-kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10775.43 Da
• Isoelectric Point: 10.5054

>T145334 WP_112474242.1 NZ_CP047019:c3860272-3859991 [Streptomyces sp. ST1015]
VGYVTRFTPHAQRDMLKISRPDALRVLHRLTELQKAMDAGDTTAFDVKALQGHSARWRLRVGDYRIVYTVEDGQMIVWVL
AVGNRRDVYRHLP

Nucleotide

• Length: 282 bp

>T145334 NZ_CP062358:2660881-2661243 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10459.64 Da
• Isoelectric Point: 4.3686

>AT145334 WP_240001224.1 NZ_CP047019:c3860558-3860277 [Streptomyces sp. ST1015]
MSDPVVESMAEVRSHLADVIDRARREETPTIITRRGKQEAVVIDIEEYRRLREVAESAEEAWLNRLADEAESEGVQGSVS
LEEMAALLRAHQG

Nucleotide

• Length: 282 bp

>AT145334 NZ_CP062358:2660714-2660884 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA