Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 36707..37299 | Replicon | plasmid pX4 |
| Accession | NZ_CP047015 | ||
| Organism | Escherichia coli strain 19-5 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | GQF95_RS25620 | Protein ID | WP_113589071.1 |
| Coordinates | 36707..36955 (+) | Length | 83 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | V0AWG0 |
| Locus tag | GQF95_RS25625 | Protein ID | WP_000681613.1 |
| Coordinates | 36952..37299 (+) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GQF95_RS25570 (GQF95_25510) | 32046..32297 | + | 252 | WP_000121743.1 | plasmid stabilization protein | - |
| GQF95_RS25575 (GQF95_25515) | 32287..32568 | + | 282 | WP_113589067.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GQF95_RS25580 (GQF95_25520) | 32592..32942 | + | 351 | WP_113589068.1 | DNA-binding protein | - |
| GQF95_RS25585 (GQF95_25525) | 33582..34097 | + | 516 | WP_001025396.1 | J domain-containing protein | - |
| GQF95_RS25590 (GQF95_25530) | 34202..34744 | + | 543 | WP_001083908.1 | hypothetical protein | - |
| GQF95_RS25595 (GQF95_25535) | 34741..34992 | + | 252 | WP_001230707.1 | hypothetical protein | - |
| GQF95_RS25600 (GQF95_25540) | 34979..35206 | + | 228 | WP_000801440.1 | hypothetical protein | - |
| GQF95_RS26150 | 35291..35959 | + | 669 | WP_251366425.1 | hypothetical protein | - |
| GQF95_RS25615 (GQF95_25555) | 36052..36402 | + | 351 | WP_000854261.1 | hypothetical protein | - |
| GQF95_RS25620 (GQF95_25560) | 36707..36955 | + | 249 | WP_113589071.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| GQF95_RS25625 (GQF95_25565) | 36952..37299 | + | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| GQF95_RS25630 (GQF95_25570) | 37662..38165 | + | 504 | WP_000781818.1 | DNA distortion polypeptide 1 | - |
| GQF95_RS25635 (GQF95_25575) | 38169..39398 | + | 1230 | WP_000539545.1 | DNA relaxase/nickase TaxC | - |
| GQF95_RS25640 (GQF95_25580) | 39475..39768 | + | 294 | WP_212483578.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| GQF95_RS25645 (GQF95_25585) | 39765..39980 | + | 216 | WP_000760375.1 | EexN family lipoprotein | - |
| GQF95_RS25650 | 40157..40333 | + | 177 | WP_000660496.1 | hypothetical protein | - |
| GQF95_RS25655 (GQF95_25590) | 40336..40956 | + | 621 | WP_001299949.1 | lytic transglycosylase domain-containing protein | - |
| GQF95_RS25660 (GQF95_25595) | 40970..41296 | + | 327 | WP_000008647.1 | TrbC/VirB2 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..46955 | 46955 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9408.05 Da Isoelectric Point: 10.4800
>T145333 WP_113589071.1 NZ_CP047015:36707-36955 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYVKGGTLKAIKQNLKEAG
LL
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYVKGGTLKAIKQNLKEAG
LL
Download Length: 249 bp
>T145333 NZ_CP062358:2639775-2639984 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 116 a.a. Molecular weight: 13113.84 Da Isoelectric Point: 4.6723
>AT145333 WP_000681613.1 NZ_CP047015:36952-37299 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
Download Length: 348 bp
>AT145333 NZ_CP062358:2639470-2639763 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|