145332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 34741..35206 Replicon plasmid pX4
Accession NZ_CP047015
Organism Escherichia coli strain 19-5

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag GQF95_RS25595 Protein ID WP_001230707.1
Coordinates 34741..34992 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag GQF95_RS25600 Protein ID WP_000801440.1
Coordinates 34979..35206 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF95_RS26145 31692..31991 - 300 WP_251366424.1 hypothetical protein -
GQF95_RS25570 (GQF95_25510) 32046..32297 + 252 WP_000121743.1 plasmid stabilization protein -
GQF95_RS25575 (GQF95_25515) 32287..32568 + 282 WP_113589067.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQF95_RS25580 (GQF95_25520) 32592..32942 + 351 WP_113589068.1 DNA-binding protein -
GQF95_RS25585 (GQF95_25525) 33582..34097 + 516 WP_001025396.1 J domain-containing protein -
GQF95_RS25590 (GQF95_25530) 34202..34744 + 543 WP_001083908.1 hypothetical protein -
GQF95_RS25595 (GQF95_25535) 34741..34992 + 252 WP_001230707.1 hypothetical protein Toxin
GQF95_RS25600 (GQF95_25540) 34979..35206 + 228 WP_000801440.1 hypothetical protein Antitoxin
GQF95_RS26150 35291..35959 + 669 WP_251366425.1 hypothetical protein -
GQF95_RS25615 (GQF95_25555) 36052..36402 + 351 WP_000854261.1 hypothetical protein -
GQF95_RS25620 (GQF95_25560) 36707..36955 + 249 WP_113589071.1 type II toxin-antitoxin system HicA family toxin -
GQF95_RS25625 (GQF95_25565) 36952..37299 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
GQF95_RS25630 (GQF95_25570) 37662..38165 + 504 WP_000781818.1 DNA distortion polypeptide 1 -
GQF95_RS25635 (GQF95_25575) 38169..39398 + 1230 WP_000539545.1 DNA relaxase/nickase TaxC -
GQF95_RS25640 (GQF95_25580) 39475..39768 + 294 WP_212483578.1 sigma factor-like helix-turn-helix DNA-binding protein -
GQF95_RS25645 (GQF95_25585) 39765..39980 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..46955 46955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T145332 WP_001230707.1 NZ_CP047015:34741-34992 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T145332 NZ_CP062358:2582378-2582482 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT145332 WP_000801440.1 NZ_CP047015:34979-35206 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT145332 NZ_CP062358:c2582640-2582477 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References